The predictive potential of Neuronatin for neoadjuvant chemotherapy of breast cancer

被引：3
|
作者：
Pieper, Willi [1 ]
Ignatov, Atanas [2 ]
Kalinski, Thomas [1 ]
Haybaeck, Johannes [1 ,3 ,4 ]
Czapiewski, Piotr [1 ,5 ]
Nass, Norbert [1 ,6 ]
机构：
[1] Otto Von Guericke Univ, Med Fac, Dept Pathol, Leipziger Str 44, D-39120 Magdeburg, Germany
[2] Otto Von Guericke Univ, Dept Obstet & Gynecol, Magdeburg, Germany
[3] Med Univ Innsbruck, Dept Pathol Neuropathol & Mol Pathol, Innsbruck, Austria
[4] Med Univ Graz, Ctr Mol BioMed, Inst Pathol, Dept Pathol Diagnost & Res, Graz, Austria
[5] Dessau Med Ctr, Dept Pathol, Dessau, Germany
[6] Dessau Med Ctr, Dept Internal Med 1, Dessau, Germany
来源：
CANCER BIOMARKERS | 2021年 / 32卷 / 02期
关键词：
Breast cancer; neoadjuvant chemotherapy; neuronatin; remission score; LAFORA DISEASE; PPAR-GAMMA; EXPRESSION; CARCINOMA; SUBTYPES; IMPACT; FORMS;
D O I：
10.3233/CBM-203127
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND: Neuronatin (NNAT) determined by immunohistochemistry is a negative prognostic biomarker for breast cancer, independent of the major clinicopathological markers. OBJECTIVE: Here, we investigated whether NNAT is also a predictive biomarker for pathological remission after neoadjuvant chemotherapy. METHODS: One hundred and four breast cancer patients, treated with systemic neoadjuvant chemotherapy were included in this retrospective study. NNAT was detected in formaldehyde fixed, paraffin embedded primary cancer tissue by immunohistochemistry and an immuno-reactive score (IRS) determined. Pathological remission was scored according to Sinn and by evaluation of cytopathic effects. NNAT-IRS was correlated with clinicopathological parameters as well as relapse free and overall survival and for pathological remission after neoadjuvant therapy. RESULTS: NNAT IRS was an independent prognostic marker for relapse free and overall survival and the time from diagnosis to the "tumor-free" state. NNAT IRS was associated with Luminal-A tumors and correlated slightly negative with age and lymph-node metastasis. There was no significant correlation of NNAT-IRS with Sinn's remission score, but with cytopathic effects of chemotherapy. CONCLUSIONS: We confirmed the prognostic impact of NNAT-IRS in an independent cohort of neoadjuvantly treated patients. Additionally, a correlation with a score for pathological remission under systemic neoadjuvant chemotherapy for breast cancer was found.
引用
收藏
页码：161 / 173
页数：13
相关论文
共 50 条
  • [31] TMB and TCR Are Correlated Indicators Predictive of the Efficacy of Neoadjuvant Chemotherapy in Breast Cancer
    Liang, Hongling
    Huang, Jia
    Ao, Xiang
    Guo, Weibang
    Chen, Yu
    Lu, Danxia
    Lv, Zhiyi
    Tan, Xiaojun
    He, Weixing
    Jiang, Ming
    Xia, Haoming
    Zhan, Yongtao
    Guo, Weiling
    Ye, Zhiqing
    Jiao, Lei
    Ma, Jie
    Wang, Changxi
    Li, Hongsheng
    Zhang, Xuchao
    Huang, Jianqing
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [32] Predictive and Prognostic Roles of Pathological Indicators for Patients with Breast Cancer on Neoadjuvant Chemotherapy
    Li, Xinyan
    Wang, Mozhi
    Wang, Mengshen
    Yu, Xueting
    Guo, Jingyi
    Sun, Tie
    Yao, Litong
    Zhang, Qiang
    Xu, Yingying
    JOURNAL OF BREAST CANCER, 2019, 22 (04) : 497 - 521
  • [33] Predictive factors associated with invasive lobular breast cancer after neoadjuvant chemotherapy
    Julian, T. B.
    Anderson, S.
    Fourchotte, V.
    Zieger, S.
    Mamounas, E.
    Bear, H.
    Costantino, J.
    Wolmark, N.
    ANNALS OF SURGICAL ONCOLOGY, 2007, 14 (02) : 17 - 17
  • [34] Predictive Factors of Response to Neoadjuvant Chemotherapy in Hormone Receptor Positive Breast Cancer
    Lai, L.
    Ottesen, R.
    Niland, J.
    ANNALS OF SURGICAL ONCOLOGY, 2014, 21 : S62 - S63
  • [35] HLA-J as a new predictive marker in breast cancer for neoadjuvant chemotherapy
    Wuerfel, F. M.
    Wirtz, R. M.
    Winterhalter, C.
    De Laco, P.
    Rosati, M.
    Veltrup, E.
    Martoni, A. A.
    Wuerfel, W.
    Zamagni, C.
    GEBURTSHILFE UND FRAUENHEILKUNDE, 2020, 80 (10) : E108 - E108
  • [36] ITPKC as a Prognostic and Predictive Biomarker of Neoadjuvant Chemotherapy for Triple Negative Breast Cancer
    Oshi, Masanori
    Newman, Stephanie
    Murthy, Vijayashree
    Tokumaru, Yoshihisa
    Yan, Li
    Matsuyama, Ryusei
    Endo, Itaru
    Takabe, Kazuaki
    CANCERS, 2020, 12 (10) : 1 - 14
  • [37] Predictive role of haemoglobin on disease response to neoadjuvant chemotherapy in breast cancer.
    Omarini, Claudia
    Iattoni, Elena
    Filieri, Maria Elisabetta
    Toss, Angela
    Grizzi, Giulia
    Del Giovane, Cinzia
    Tamma, Antonella Valentina
    Cascinu, Stefano
    Piacentini, Federico
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [38] Predictive value of microenvironment for progression in breast cancer patients treated with neoadjuvant chemotherapy
    Goto, Wataru
    Kashiwagi, Shinichiro
    Asano, Yuka
    Takada, Koji
    Takahashi, Katsuyuki
    Noda, Satoru
    Takashima, Tsutomu
    Onoda, Naoyoshi
    Tomita, Shuhei
    Hirakawa, Kosei
    Ohira, Masaichi
    CANCER SCIENCE, 2018, 109 : 123 - 123
  • [39] Circulating Exosomal microRNAs as Predictive Biomarkers of Neoadjuvant Chemotherapy Response in Breast Cancer
    Todorova, Valentina K.
    Byrum, Stephanie D.
    Gies, Allen J.
    Haynie, Cade
    Smith, Hunter
    Reyna, Nathan S.
    Makhoul, Issam
    CURRENT ONCOLOGY, 2022, 29 (02) : 613 - 630
  • [40] Mammographic breast density: Predictive value for pathological response to neoadjuvant chemotherapy in breast cancer patients
    Elsamany, S.
    Alzahrani, A.
    Abozeed, W. N.
    Rasmy, A.
    Farooq, M. U.
    Elbiomy, M. A.
    Rawah, E.
    Alsaleh, K.
    Abdel-Aziz, N. M.
    BREAST, 2015, 24 (05): : 576 - 581
12345