Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection

被引：50
|
作者：
de Swart, Rik L. [1 ]
van den Hoogen, Bernadette G. [1 ]
Kuiken, Thijs [1 ]
Herfst, Sander [1 ]
van Amerongen, Geert [1 ]
Yuksel, Selma [1 ]
Sprong, Leo [1 ]
Osterhaus, Albert D. M. E. [1 ]
机构：
[1] Erasmus MC, Dept Virol, NL-3000 CA Rotterdam, Netherlands
来源：
VACCINE | 2007年 / 25卷 / 51期
关键词：
hMPV; vaccination; formaldehyde; immunopathology; paramyxovirus;
D O I：
10.1016/j.vaccine.2007.10.022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Human metapneumovirus (hMPV), a member of the family Paramyxovifidae, is an important cause of acute respiratory tract disease. In the 1960s, vaccination with formalin-inactivated paramyxovirus preparations - respiratory syncytial virus (RSV) and measles virus (MV) resulted in predisposition for enhanced disease upon natural infection. We have produced a formalin-inactivated hMPV preparation (FI-hMPV), which was used to immunize young cynomolgus macaques. Six days after challenge FI-hMPV-primed monkeys had developed eosinophilic bronchitis and bronchiolitis, indicative of a hypersensitivity response. This study indicates that formalin-inactivated hMPV vaccines have the same propensity to predispose for immune-mediated disease as inactivated RSV and MV vaccines. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：8518 / 8528
页数：11
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