Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection

被引：50

作者：

de Swart, Rik L. ^{[1
]}

van den Hoogen, Bernadette G. ^{[1
]}

Kuiken, Thijs ^{[1
]}

Herfst, Sander ^{[1
]}

van Amerongen, Geert ^{[1
]}

Yuksel, Selma ^{[1
]}

Sprong, Leo ^{[1
]}

Osterhaus, Albert D. M. E. ^{[1
]}

机构：

[1] Erasmus MC, Dept Virol, NL-3000 CA Rotterdam, Netherlands

来源：

VACCINE | 2007年 / 25卷 / 51期

关键词：

hMPV; vaccination; formaldehyde; immunopathology; paramyxovirus;

D O I：

10.1016/j.vaccine.2007.10.022

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human metapneumovirus (hMPV), a member of the family Paramyxovifidae, is an important cause of acute respiratory tract disease. In the 1960s, vaccination with formalin-inactivated paramyxovirus preparations - respiratory syncytial virus (RSV) and measles virus (MV) resulted in predisposition for enhanced disease upon natural infection. We have produced a formalin-inactivated hMPV preparation (FI-hMPV), which was used to immunize young cynomolgus macaques. Six days after challenge FI-hMPV-primed monkeys had developed eosinophilic bronchitis and bronchiolitis, indicative of a hypersensitivity response. This study indicates that formalin-inactivated hMPV vaccines have the same propensity to predispose for immune-mediated disease as inactivated RSV and MV vaccines. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：8518 / 8528

页数：11

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