DNA replication: Building the perfect switch

被引：81
|
作者：
Diffley, JFX [1 ]
机构：
[1] Imperial Canc Res Fund, Clare Hall Labs, S Mimms EN6 3LD, Herts, England
来源：
CURRENT BIOLOGY | 2001年 / 11卷 / 09期
关键词：
D O I：
10.1016/S0960-9822(01)00196-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
a sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.
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页码：R367 / R370
页数：4
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