Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis

被引：70
|
作者：
Little, Rory F. [1 ]
Hertweck, Christian [1 ]
机构：
[1] HKI, Leibniz Inst Nat Prod Res & Infect Biol, Jena, Germany
来源：
NATURAL PRODUCT REPORTS | 2022年 / 39卷 / 01期
关键词：
STREPTOMYCES-COELICOLOR PATHWAY; IN-VITRO RECONSTITUTION; ACYL-CARRIER PROTEIN; GENE-CLUSTER; THIOESTERASE DOMAIN; STRUCTURAL BASIS; HETEROLOGOUS EXPRESSION; REDUCTASE DOMAINS; NATURAL-PRODUCTS; BOND FORMATION;
D O I：
10.1039/d1np00035g
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide natural products is strongly influenced by how they are released from their biosynthetic enzymes. As such, Nature has evolved a diverse range of release mechanisms, leading to the formation of bioactive chemical scaffolds such as lactones, lactams, diketopiperazines, and tetronates. Here, we review the enzymes and mechanisms used for chain release in polyketide and non-ribosomal peptide biosynthesis, how these mechanisms affect natural product structure, and how they could be utilised to introduce structural diversity into the products of engineered biosynthetic pathways.
引用
收藏
页码：163 / 205
页数：43
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