AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats

被引：3
|
作者：
Li, Dan [1 ]
Ye, Feng [2 ]
Ouyang, Wen [1 ]
Wang, Yi [1 ]
机构：
[1] Cent S Univ, Xiangya Hosp 3, Dept Anesthesiol, 138 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China
[2] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ China, Affiliated Hosp 2, Chongqing 400010, Peoples R China
来源：
JOURNAL OF ANESTHESIA | 2017年 / 31卷 / 06期
基金：
中国国家自然科学基金;
关键词：
AMP-activated protein kinase; cAMP response element-binding protein; Postoperative cognitive dysfunction; COGNITIVE DYSFUNCTION; AGED RATS; PLASTICITY; DECLINE; NEUROINFLAMMATION; INHIBITION; IMPAIRMENT; PROTECTION; SURGERY; BRAIN;
D O I：
10.1007/s00540-017-2398-z
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
To explore the association of AMP-activated protein kinase (AMPK) and cAMP response element-binding protein (CREB) activity with distinct postoperative behavioral changes in rats. We performed partial hepatolobectomy in adult rats and aged rats. The learning and memory ability of rats was evaluated by the Barnes maze test on postoperative days 1-4. The expressions of AMPK and phosphorylated CREB (p-CREB) in the CA1 and DG regions of the hippocampus were detected by immunohistochemical assay at 3, 6, 12 and 24 h postoperatively. Surgery impaired the memory of aged rats but not that of adult rats on postoperative days 2 and 3 (both p < 0.05). Surgery synergistically increased the expressions of AMPK and p-CREB in the CA1 region of hippocampus in aged rats but not in adult rats at 3 and 6 h postoperatively. Our data suggest that surgery induces cognitive impairment in aged rats. Surgery-induced expression of AMPK and p-CREB in the CA1 region of hippocampus may be involved in this cognitive impairment.
引用
收藏
页码：806 / 812
页数：7
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