Paths to understanding the genetic basis of autoimmune disease

被引：147
|
作者：
Rioux, JD
Abbas, AK
机构：
[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Broad Inst MIT & Harvard, Cambridge, MA 02139 USA
[2] Univ Montreal, Montreal Heart Inst, Montreal, PQ H3C 3J7, Canada
[3] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA
来源：
NATURE | 2005年 / 435卷 / 7042期
关键词：
D O I：
10.1038/nature03723
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances in genetic resources and tools are now making it possible to identify the sequence variants that contribute to autoimmune diseases - promising a better understanding of how we normally remain tolerant of our own tissue components, and how this goes wrong in autoimmune disease.
引用
收藏
页码：584 / 589
页数：6
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