Biochemical studies on the role of lycopene in the protection of mice against microcystin toxicity

被引：10
|
作者：
Al-Jassabi, S [1 ]
机构：
[1] Yarmouk Univ, Dept Biol Sci, Irbid 21163, Jordan
来源：
CHEMISTRY AND ECOLOGY | 2005年 / 21卷 / 02期
关键词：
chemoprotection; toxicity; microcystin; lycopene;
D O I：
10.1080/02757540500093089
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The presence of cyanobacterial toxins in drinking and recreational waters represents a potential risk to public health. Microcystin-LR (MC-LR) is a potent cyclic heptapeptide hepatotoxin produced by the blue-green alga Microcystis (teruginosa. Chemoprotectant studies suggest that membrane-active antioxidants may offer a protection against microcystin toxicity. The aim of this study is to investigate the potential benefits of dietary supplementation of lycopene as antioxidants on microcystin toxicity in mouse liver. A group of Balb/c was pre-treated for 2 weeks with lycopene (10 mg/mouse/d) before an intraperitoneal injection (i.p.) of MC-LR. The potential benefits of lycopene were evaluated based on lipid peroxidation, alanine transaminase (ALT), glutathione peroxidase (GPX) and glutathione-S-transferase (GST) levels. Therefore, lycopene Supplied as a dietary supplement may have a protective effect against chronic exposure to MC-LR.
引用
收藏
页码：143 / 148
页数：6
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