Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections

被引：29
|
作者：
Ying, Tianlei [1 ]
Li, Haoyang [1 ]
Lu, Lu [1 ]
Dimitrov, Dimiter S. [2 ]
Jiang, Shibo [1 ,3 ]
机构：
[1] Fudan Univ, Shanghai Med Coll, Key Lab Med Mol Virol MOE MOH, Shanghai 200032, Peoples R China
[2] NCI, Prot Interact Sect, Canc & Inflammat Program, Ctr Canc Res,NIH, Frederick, MD 21702 USA
[3] New York Blood Ctr, Lindsley F Kimball Res Inst, New York, NY 10065 USA
来源：
MICROBES AND INFECTION | 2015年 / 17卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Coronavirus; MERS-CoV; mAbs; Receptor binding domain (RBD); RESPIRATORY SYNDROME CORONAVIRUS; RECEPTOR-BINDING DOMAIN; POTENT NEUTRALIZATION; SARS CORONAVIRUS; BAT CORONAVIRUS; SPIKE PROTEIN; SAUDI-ARABIA; VIRUS; IDENTIFICATION; THERAPEUTICS;
D O I：
10.1016/j.micinf.2014.11.008
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The recent Middle East respiratory syndrome coronavirus (MERS-CoV) outbreak poses a serious threat to public health. Here, we summarize recent advances in identifying human neutralizing monoclonal antibodies (mAbs) against MERS-CoV, describe their mechanisms of action, and analyze their potential for treatment of MERS-CoV infections. (C) 2014 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：142 / 148
页数：7
相关论文
共 50 条
  • [31] Comparison of incubation period distribution of human infections with MERS-CoV in South Korea and Saudi Arabia
    Virlogeux, Victor
    Fang, Vicky J.
    Park, Minah
    Wu, Joseph T.
    Cowling, Benjamin J.
    SCIENTIFIC REPORTS, 2016, 6
  • [32] Number of New Infections dropped significantly Decline in MERS-CoV Infections in the Middle East
    Loesch, Raymund
    Klare, Unn
    FLUGMEDIZIN TROPENMEDIZIN REISEMEDIZIN, 2014, 21 (04): : 170 - 170
  • [33] Protein nanoparticle vaccines induce potent neutralizing antibody responses against MERS-CoV
    Chao, Cara W.
    Sprouse, Kaitlin R.
    Miranda, Marcos C.
    Catanzaro, Nicholas J.
    Hubbard, Miranda L.
    Addetia, Amin
    Stewart, Cameron
    Brown, Jack T.
    Dosey, Annie
    Valdez, Adian
    Ravichandran, Rashmi
    Hendricks, Grace G.
    Ahlrichs, Maggie
    Dobbins, Craig
    Hand, Alexis
    Mcgowan, Jackson
    Simmons, Boston
    Treichel, Catherine
    Willoughby, Isabelle
    Walls, Alexandra C.
    Mcguire, Andrew T.
    Leaf, Elizabeth M.
    Baric, Ralph S.
    Schafer, Alexandra
    Veesler, David
    King, Neil P.
    CELL REPORTS, 2024, 43 (12):
  • [34] Middle East respiratory syndrome coronavirus (MERS-CoV): Prevention in travelers
    Pavli, Androula
    Tsiodras, Sotirios
    Maltezou, Helena C.
    TRAVEL MEDICINE AND INFECTIOUS DISEASE, 2014, 12 (06) : 602 - 608
  • [35] Imaging findings in coronavirus infections: SARS-CoV, MERS-CoV, and SARS-CoV-2
    Franquet, Tomas
    Jeong, Yeon Joo
    Lam, Hiu Yin Sonia
    Wong, Ho Yuen Frank
    Chang, Yeun-Chung
    Chung, Myung Jin
    Lee, Kyung Soo
    BRITISH JOURNAL OF RADIOLOGY, 2020, 93 (1112):
  • [36] Development of A MERS-CoV Replicon Cell Line for Antiviral Screening
    Jing Chen
    BingJie Hu
    Kai Zhao
    Yun Luo
    HaoFeng Lin
    ZhengLi Shi
    Virologica Sinica, 2021, 36 (04) : 730 - 735
  • [37] Sustained Responses of Neutralizing Antibodies Against Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in Recovered Patients and Their Therapeutic Applicability
    Kim, Yeon-Sook
    Aigerim, Abdimadiyeva
    Park, Uni
    Kim, Yuri
    Park, Hyoree
    Rhee, Ji-Young
    Choi, Jae-Phil
    Park, Wan Beom
    Park, Sang Won
    Kim, Yeonjae
    Lim, Dong-Gyun
    Choi, Ji-Yeob
    Jeon, Yoon Kyung
    Yang, Jeong-Sun
    Lee, Joo-Yeon
    Shin, Hyoung-Shik
    Cho, Nam-Hyuk
    CLINICAL INFECTIOUS DISEASES, 2021, 73 (03) : E550 - E558
  • [38] Production of a Monoclonal Antibody Targeting the M Protein of MERS-CoV for Detection of MERS-CoV Using a Synthetic Peptide Epitope Formulated with a CpG–DNA–Liposome Complex
    Byoung Kwon Park
    Su In Lee
    Joon-Yong Bae
    Man-Seong Park
    Younghee Lee
    Hyung-Joo Kwon
    International Journal of Peptide Research and Therapeutics, 2019, 25 : 819 - 826
  • [39] CLINICAL DEVELOPMENT OF VIRAL VECTORED VACCINES AGAINST MERS-COV
    Ewer, Katie
    Folegatti, Pedro
    Bellamy, Duncan
    Mair, Catherine
    Alharbi, Naif
    Lambe, Teresa
    Wright, Danny
    Warimwe, George
    Gilbert, Sarah
    AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2018, 99 (04): : 305 - 306
  • [40] Development of A MERS-CoV Replicon Cell Line for Antiviral Screening
    Chen, Jing
    Hu, Bing-Jie
    Zhao, Kai
    Luo, Yun
    Lin, Hao-Feng
    Shi, Zheng-Li
    VIROLOGICA SINICA, 2021, 36 (04) : 730 - 735
12345