The CALHM1 P86L Polymorphism is a Genetic Modifier of Age at Onset in Alzheimer's Disease: a Meta-Analysis Study

被引：50

作者：

Lambert, Jean-Charles ^{[1
,2
]}

Sleegers, Kristel ^{[3
]}

Gonzalez-Perez, Antonio ^{[6
]}

Ingelsson, Martin ^{[7
]}

Beecham, Gary W. ^{[8
]}

Hiltunen, Mikko ^{[9
,10
]}

Combarros, Onofre ^{[11
,12
]}

Bullido, Maria J. ^{[13
,14
]}

Brouwers, Nathalie ^{[3
,4
,5
]}

Bettens, Karolien ^{[3
,4
,5
]}

Berr, Claudine ^{[15
]}

Pasquier, Florence ^{[2
,16
]}

Richard, Florence ^{[1
,2
,16
]}

DeKosky, Steven T. ^{[17
]}

Hannequin, Didier ^{[18
]}

Haines, Jonathan L. ^{[19
]}

Tognoni, Gloria ^{[20
]}

Fievet, Nathalie ^{[1
]}

Dartigues, Jean-Francois ^{[21
]}

Tzourio, Christophe ^{[22
,23
]}

Engelborghs, Sebastiaan ^{[24
,25
]}

Arosio, Beatrice ^{[26
]}

Coto, Elicer ^{[27
]}

De Deyn, Peter ^{[4
,5
,24
,25
]}

Del Zompo, Maria ^{[28
]}

Mateo, Ignacio ^{[11
,12
]}

Boada, Merce ^{[29
,30
]}

Antunez, Carmen ^{[31
,32
]}

Lopez-Arrieta, Jesus ^{[33
]}

Epelbaum, Jacques ^{[34
]}

Schjcide, Brit-Marcn Michaud ^{[35
]}

Frank-Garcia, Ana ^{[36
,37
]}

Gicdraitis, Vilmentas ^{[7
]}

Helisalmi, Seppo ^{[11
,12
]}

Porcellini, Elisa ^{[38
]}

Pilotto, Alberto ^{[39
]}

Forti, Paola ^{[40
]}

Ferri, Raffaele ^{[41
]}

Delepine, Marc ^{[42
]}

Zelenika, Diana ^{[42
]}

Lathrop, Mark ^{[42
,43
]}

Scarpini, Elio ^{[44
]}

Siciliano, Gabriele ^{[20
]}

Solfrizzi, Vincenzo ^{[45
]}

Sorbi, Sandro ^{[18
,46
]}

Spalletta, Gianfranco ^{[47
]}

Ravaglia, Giovanni

Valdivieso, Fernando ^{[14
]}

Vepsalainen, Saila ^{[7
]}

Alvarez, Victoria

机构：

[1] Inst Pasteur, Unite INSERM 744, BP 245,1 Rue,Professeur Calmette, F-59019 Lille, France

[2] Univ Lille Nord France, Lille, France

[3] Dept Mol Genet VIB, Neurodegenerat Brain Dis Grp, Antwerp, Belgium

[4] Univ Antwerp, B-2020 Antwerp, Belgium

[5] Inst Born Bunge, Antwerp, Belgium

[6] Dept Struct Genom, Seville, Spain

[7] Uppsala Univ, Stockholm, Sweden

[8] Univ Miami, Sch Med, John P Hussman Inst Human Gen, Miami, FL USA

[9] Univ Hosp, Kuopio, Finland

[10] Univ Kuopio, Dept Neurol, Kuopio, Finland

[11] Univ Cantabria, Marques Valdecilla Univ Hosp, Neurol Serv, Santander, Spain

[12] Univ Cantabria, CIBERNED, Santander, Spain

[13] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa UAM CSIC, Madrid, Spain

[14] Univ Autonoma Madrid, CIBERNED, Madrid, Spain

[15] Hop Colombiere, INSERM U888, Montpellier, France

[16] CHRU Lille, Lille, France

[17] Univ Virginia, Sch Med, Charlottesville, VA 22908 USA

[18] Fac Med Pharmacie Rouen, INSERM U614, Rouen, France

[19] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Human Genet Res, Nashville, TN USA

[20] Univ Pisa, Dept Neurosci, Neurol Clin, Pisa, Italy

[21] Victor Segalen Univ, INSERM U897, Bordeaux, France

[22] INSERM U708, Paris, France

[23] UPMC Univ Paris 06, Paris, France

[24] ZNA Middelheim, Memory Clin, Antwerp, Belgium

[25] ZNA Middelheim, Dept Neurol, Antwerp, Belgium

[26] Fdn Policlin IRCCS, Dept Internal Med, Milan, Italy

[27] Hosp Univ Cent Asturias, Mol Genet Unit, Oviedo, Spain

[28] Univ Cagliari, Dept Neurosci, Clin Pharmacol Sect, Cagliari, Italy

[29] Memory Clin Fdn ACE, Inst Neurociencies Aplicades, Barcelona, Spain

[30] Hosp G Univ Vall Hebron, Dept Neurol, Barcelona, Spain

[31] Alzheimur Fdn, Murcia, Spain

[32] Univ Hosp Virgen Arrixaca, Dementia Unit, Murcia, Spain

[33] Univ Hosp Paz Cantoblanco, Memory Unit, Madrid, Spain

[34] Univ Paris 05, UMR 894, INSERM Fac Med, Paris, France

[35] Max Planck Inst Mol Genet, Neuropsychiat Genet Grp, Dept Vertebrate Gen, Berlin, Germany

[36] Hosp Univ La Paz UAM, Serv Neurol, Madrid, Spain

[37] CIBERNED, Madrid, Spain

[38] Univ Bologna, Sch Med, Dept Expt Pathol, Bologna, Italy

[39] IRCCS Casa Sollievo Sofferenza, Dept Med Sci, Geriatr Unit & Gerontol Geriatr Res Lab, San Giovanni Rotondo, Italy

[40] Univ Hosp S Orsola Malpighi, Dept Internal Med Cardiol & Hepatol, Bologna, Italy

[41] IRCCS Oasi Maria SS, Troina, Italy

[42] Inst Genom, Commissariat Energie Atom, Ctr Natl Genotypage, Evry, France

[43] Fdn Jean Dausset CEPH, Paris, France

[44] Univ Milan, Dept Neurol Sci, Dino Ferrari Ctr, IRCCS Osped Maggiore Policlin, Milan, Italy

[45] Univ Bari, Dept Geriatr, Ctr Aging Brain, Memory Unit, Bari, Italy

[46] Dept Neurol & Psychiat Sci, Florence, Italy

[47] IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Rome, Italy

[48] Univ Milano Bicocca, Dept Clin Med & Prevent, Monza, Italy

[49] Univ Manchester, Greater Manchester Neurosci Ctr, Manchester, Lancs, England

[50] N Shore LIJ, Feinstein Inst Med Res, Litwin Zucker Res Ctr Study Alzheimers Dis, Manhasset, NY USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 22卷 / 01期

基金：

芬兰科学院;

关键词：

Age at onset; Alzheimer's disease; apolipoprotein E; CALHM1; polymorphism; GENOME-WIDE ASSOCIATION; S-TRANSFERASE OMEGA-1; NO ASSOCIATION; AT-ONSET; POPULATION-STRUCTURE; IDENTIFIES VARIANTS; RISK; HETEROGENEITY; HOMEOSTASIS; DEMENTIA;

D O I：

10.3233/JAD-2010-100933

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the epsilon 4 allele of the APOE gene.

引用

页码：247 / 255

页数：9

共 50 条

[31] Genetic polymorphism of interleukin 1β-511C/T and susceptibility to sporadic Alzheimer's disease: a meta-analysis
Yuan, Hai
Xia, Qing
Ge, Pingping
Wu, Shaowei
MOLECULAR BIOLOGY REPORTS, 2013, 40 (02) : 1827 - 1834
[32] Association of the CR1 polymorphism with late-onset Alzheimer's disease in Chinese Han populations: A meta-analysis
Jin, Chunhui
Li, Weidong
Yuan, Jianmin
Xu, Wenwei
Cheng, Zaohuo
NEUROSCIENCE LETTERS, 2012, 527 (01) : 46 - 49
[33] Association of HLA-DRB1 polymorphism with Alzheimer's disease: a replication and meta-analysis
Lu, Rui-Chun
Yang, Wu
Tan, Lin
Sun, Fu-Rong
Tan, Meng-Shan
Zhang, Wei
Wang, Hui-Fu
Tan, Lan
ONCOTARGET, 2017, 8 (54) : 93219 - 93226
[34] Interleukin-1B polymorphism is associated with age at onset of Alzheimer's disease
Sciacca, FL
Ferri, C
Licastro, F
Veglia, F
Biunno, I
Gavazzi, A
Calabrese, E
Boneschi, FM
Sorbi, S
Mariani, C
Franceschi, M
Grimaldi, LME
NEUROBIOLOGY OF AGING, 2003, 24 (07) : 927 - 931
[35] Age-dependent association between interleukin-1A (-889) genetic polymorphism and sporadic Alzheimer’s diseaseA meta-analysis
O. Combarros
J. Llorca
M. Sanchez-Guerra
J. Infante
J. Berciano
Journal of Neurology, 2003, 250 : 987 - 989
[36] Association between APOC1 Polymorphism and Alzheimer's Disease: A Case-Control Study and Meta-Analysis
Zhou, Qin
Zhao, Fan
Lv, Ze-ping
Zheng, Chen-guang
Zheng, Wei-dong
Sun, Liang
Wang, Na-na
Pang, Shenghang
de Andrade, Fabiana Michelsen
Fu, Mian
He, Xiang-hua
Hui, Juan
Jiang, Wen-yu
Yang, Chu-yu
Shi, Xiao-hong
Zhu, Xiao-quan
Pang, Guo-fang
Yang, Yi-ge
Xie, Hai-qun
Zhang, Wan-dong
Hu, Cai-you
Yang, Ze
PLOS ONE, 2014, 9 (01):
[37] TP53 R72P POLYMORPHISM AS A MODIFIER OF AGE AT ONSET OF HUNTINGTON'S DISEASE
Tunali, N. E.
Acar-Hazer, A.
Erginel-Unaltuna, N.
Hanagasi, H. A.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2010, 81 : A17 - A17
[38] Apolipoprotein E genetic variation and Alzheimer's disease - A meta-analysis
Rubinsztein, DC
Easton, DF
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 1999, 10 (03) : 199 - 209
[39] Apolipoprotein E genetic variation and Alzheimer's Disease - A meta-analysis
Rubinsztein, DC
Easton, EF
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2000, 11 (04) : 238 - 238
[40] Bilingualism for delaying the onset of Alzheimer's disease: a systematic review and meta-analysis
Paulavicius, Andrea M.
Mizzaci, Carolina C.
Tavares, Daniela R. B.
Rocha, Aline P.
Civile, Vinicius T.
Schultz, Rodrigo R.
Pinto, Ana Carolina Pereira Nunes
Trevisani, Virginia F. M.
EUROPEAN GERIATRIC MEDICINE, 2020, 11 (04) : 651 - 658

← 1 2 3 4 5 →