Inhibition of linoleic acid hydroperoxide-induced toxicity in cultured human fibroblasts by anthocyanidins

被引：14
|
作者：
Kaneko, T
Tahara, S
Baba, N
机构：
[1] Tokyo Metropolitan Inst Gerontol, Redox Regulat Res Grp, Itabashi Ku, Tokyo 1730015, Japan
[2] Okayama Univ, Fac Agr, Okayama 7000082, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 06期
关键词：
anthocyanidin; cytotoxicity; linoleic acid hydroperoxide; lipid peroxide; human fibroblasts;
D O I：
10.1271/bbb.67.1391
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The protective effect of anthocyanidins against the toxicity induced by linoleic acid hydroperoxide (LOOH) was examined in cultured human fetal lung fibroblasts, TIG-7. Cyanidin was more effective than pelargonidin or delphinidin in inhibiting LOOH-induced cytotoxicity. The presence of a catechol moiety in the B ring is shown to be important for the protective activities against the cytotoxicity of LOOH.
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页码：1391 / 1393
页数：3
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