SLC22A16 upregulation is an independent unfavorable prognostic indicator in gastric cancer

被引：12
|
作者：
Zhao, Wenhua [1 ]
Wang, Yongbin [2 ]
Yue, Xin [3 ]
机构：
[1] Peoples Hosp Juxian, Dept Clin Lab Diag, Rizhao 276500, Shandong, Peoples R China
[2] Matern & Child Hlth Care Hosp Laizhou, Clin Lab, Laizhou 261499, Peoples R China
[3] Matern & Child Hlth Care Hosp Zibo, Clin Lab, Zibo 255029, Peoples R China
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 21期
关键词：
gastric cancer; methylation; prognosis; SLC22A16; TRANSPORTER SLC22A16; CELLS; EXPRESSION; GROWTH; OCT6;
D O I：
10.2217/fon-2018-0207
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim:To study the expression profile of SLC22A16 in gastric cancer (GC), its prognostic value and the potential mechanisms of its upregulation. Patients & methods: A retrospective study was performed by using data in the Human Protein Atlas and The Cancer Genome Atlas-Stomach Cancer (STAD). Results:SLC22A16 was significantly upregulated in GC tissues compared with normal stomach tissues. SLC22A16 upregulation independently predicted poor overall survival(hazard ratio [HR]: 1.424,95% CI: 1.169-1.735; p<0.001) and recurrence-free survival (HR: 1.658, 95% CI: 1.292-2.128; p<0.001) in early GC and poor overall survival (HR: 1.411, 95%CI: 1.137-1.752; p=0.002) in advanced GC. SLC22A16 DNA hypomethylation might be a compensation for DNA loss to maintain SLC22A16 elevation in GC. Conclusion:SLC22A16 might be a valuable prognostic marker in GC.
引用
收藏
页码：2139 / 2148
页数：10
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