SLC22A16 upregulation is an independent unfavorable prognostic indicator in gastric cancer

被引：12
|
作者：
Zhao, Wenhua [1 ]
Wang, Yongbin [2 ]
Yue, Xin [3 ]
机构：
[1] Peoples Hosp Juxian, Dept Clin Lab Diag, Rizhao 276500, Shandong, Peoples R China
[2] Matern & Child Hlth Care Hosp Laizhou, Clin Lab, Laizhou 261499, Peoples R China
[3] Matern & Child Hlth Care Hosp Zibo, Clin Lab, Zibo 255029, Peoples R China
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 21期
关键词：
gastric cancer; methylation; prognosis; SLC22A16; TRANSPORTER SLC22A16; CELLS; EXPRESSION; GROWTH; OCT6;
D O I：
10.2217/fon-2018-0207
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim:To study the expression profile of SLC22A16 in gastric cancer (GC), its prognostic value and the potential mechanisms of its upregulation. Patients & methods: A retrospective study was performed by using data in the Human Protein Atlas and The Cancer Genome Atlas-Stomach Cancer (STAD). Results:SLC22A16 was significantly upregulated in GC tissues compared with normal stomach tissues. SLC22A16 upregulation independently predicted poor overall survival(hazard ratio [HR]: 1.424,95% CI: 1.169-1.735; p<0.001) and recurrence-free survival (HR: 1.658, 95% CI: 1.292-2.128; p<0.001) in early GC and poor overall survival (HR: 1.411, 95%CI: 1.137-1.752; p=0.002) in advanced GC. SLC22A16 DNA hypomethylation might be a compensation for DNA loss to maintain SLC22A16 elevation in GC. Conclusion:SLC22A16 might be a valuable prognostic marker in GC.
引用
收藏
页码：2139 / 2148
页数：10
相关论文
共 50 条
  • [1] Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16
    Sagwal, Sanjeev Kumar
    Pasqual-Melo, Gabriella
    Bodnar, Yana
    Gandhirajan, Rajesh Kumar
    Bekeschus, Sander
    CELL DEATH & DISEASE, 2018, 9
  • [2] Combination of chemotherapy and physical plasma elicits melanoma cell death via upregulation of SLC22A16
    Sanjeev Kumar Sagwal
    Gabriella Pasqual-Melo
    Yana Bodnar
    Rajesh Kumar Gandhirajan
    Sander Bekeschus
    Cell Death & Disease, 9
  • [3] Novel SLC22A16 polymorphisms and influence on doxorubicin pharmacokinetics in Asian breast cancer patients
    Lal, Suman
    Wong, Zee Wan
    Jada, Srinivasa Rao
    Xiang, Xiaoqiang
    Shu, Xiao Chen
    Ang, Peter Cher Siang
    Figg, William D.
    Lee, Edmund J. D.
    Chowbay, Balram
    PHARMACOGENOMICS, 2007, 8 (06) : 567 - 575
  • [4] Characterization of the organic cation transporter SLC22A16: A doxorubicin importer
    Okabe, M
    Unno, M
    Harigae, H
    Kaku, M
    Okitsu, Y
    Sasaki, T
    Mizoi, T
    Shiiba, K
    Takanaga, H
    Terasaki, T
    Matsuno, S
    Sasaki, I
    Ito, S
    Abe, T
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 333 (03) : 754 - 762
  • [5] Expression of organic cation transporter SLC22A16 in human endometria
    Sato, Naoko
    Ito, Kiyoshi
    Onogawa, Toru
    Akahira, Jun-ichi
    Unno, Michiaki
    Abe, Takaaki
    Niikura, Hitoshi
    Yaegashi, Nobuo
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2007, 26 (01) : 53 - 60
  • [6] Altered carnitine transporter genes (SLC22A5, SLC22A16, SLC6A14) expression pattern among lung cancer patients
    Kedzia, Konrad
    Szmajda-Krygier, Dagmara
    Krygier, Adrian
    Jablonski, Slawomir
    Balcerczak, Ewa
    Wcislo, Szymon
    TRANSLATIONAL LUNG CANCER RESEARCH, 2024, 13 (11) : 2903 - 2917
  • [7] Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer
    Kominea, A
    Konstantinopoulos, PA
    Kapranos, N
    Vandoros, G
    Gkermpesi, M
    Andricopoulos, P
    Artelaris, S
    Savva, S
    Varakis, I
    Sotiropoulou-Bonikou, G
    Papavassiliou, AG
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2004, 130 (05) : 253 - 258
  • [8] Androgen receptor (AR) expression is an independent unfavorable prognostic factor in gastric cancer
    A. Kominea
    P. A. Konstantinopoulos
    N. Kapranos
    G. Vandoros
    M. Gkermpesi
    P. Andricopoulos
    S. Artelaris
    S. Savva
    I. Varakis
    G. Sotiropoulou-Bonikou
    A. G. Papavassiliou
    Journal of Cancer Research and Clinical Oncology, 2004, 130 : 253 - 258
  • [9] Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: A possible role of the adriamycin importer
    Ota, Kyoko
    Ito, Kiyoshi
    Akahira, Jun-ichi
    Sato, Naoko
    Onogawa, Tohru
    Moriya, Takuya
    Unno, Michlaki
    Abe, Takaaki
    Niikura, Hitoshi
    Takano, Tadao
    Yaegashi, Nobuo
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 2007, 26 (03) : 334 - 340
  • [10] Long Noncoding RNA 6302 Regulates Chicken Preadipocyte Differentiation by Targeting SLC22A16
    Ma, Xiangfei
    He, Yuehua
    Liu, Cong
    Zhu, Tingqi
    Li, Donghua
    Li, Wenting
    Sun, Guirong
    Kang, Xiangtao
    GENES, 2024, 15 (06)
12345