Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes

被引：439
|
作者：
Shen, HM
Peters, A
Baron, B
Zhu, XD
Storb, U [1 ]
机构：
[1] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60617 USA
[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60617 USA
[3] Univ Chicago, Dept Pathol, Chicago, IL 60617 USA
[4] Univ Chicago, Dept Med, Chicago, IL 60617 USA
来源：
SCIENCE | 1998年 / 280卷 / 5370期
关键词：
D O I：
10.1126/science.280.5370.1750
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Immunoglobulin (Ig) genes are hypermutated in B lymphocytes that are the precursors to memory B cells. The mutations are linked to transcription initiation, but non-Ig promoters are permissible for the mutation process; thus, other genes expressed in mutating B cells may also be subject to somatic hypermutation. Significant mutations were not observed in c-MYC, S14, or alpha-fetoprotein (AFP) genes, but BCL-6 was highly mutated in a large proportion of memory B cells of normal individuals. The mutation pattern was similar to that of Ig genes.
引用
收藏
页码：1750 / 1752
页数：3
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