Copper(II) tetrafluoroborate as a novel and highly efficient catalyst for Michael addition of mercaptans to α,β-unsaturated carbonyl compounds

被引：120
|
作者：
Garg, SK [1 ]
Kumar, R [1 ]
Chakraborti, AK [1 ]
机构：
[1] NIPER, Dept Med Chem, Nagar 160062, Punjab, India
来源：
TETRAHEDRON LETTERS | 2005年 / 46卷 / 10期
关键词：
Michael addition; thiol; alpha; beta-unsaturated carbonyl; copper(II) tetrafluoroborate; catalyst;
D O I：
10.1016/j.tetlet.2005.01.051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper(II) tetrafluoroborate has been found to be a new and highly efficient catalyst for Michael addition of thiols to alpha,beta-unsaturated carbonyl compounds under solvent-free conditions and in H2O at room temperature. The reactions are very fast and are completed in 2 min to 1 h affording high yields. The rate of thiol addition was dependent on the steric hindrance at the beta-carbon of the alpha,beta-unsaturated carbonyl substrate. In the case of chalcones, the reactions are best carried out in MeOH as solvent. (C) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1721 / 1724
页数：4
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