CS-semi5 Inhibits NF-κB Activation to Block Synovial Inflammation, Cartilage Loss and Bone Erosion Associated With Collagen-Induced Arthritis

被引：7
|
作者：
Li, Xiang [1 ]
Tang, Xiaonan [1 ]
Wang, Yufei [1 ]
Chai, Changwei [1 ]
Zhao, Zhehui [1 ]
Zhang, Haijing [1 ]
Peng, Ying [1 ]
Wu, Lianqiu [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2021年 / 12卷
关键词：
rheumatoid arthritis; synovial inflammation; cartilage erosion; bone loss; chondroitin sulfate; RHEUMATOID-ARTHRITIS; CHONDROITIN SULFATE; OSTEOCLAST DIFFERENTIATION; GLUCOSAMINE SULFATE; CYTOKINES; TISSUE; RECOMMENDATIONS; OSTEOARTHRITIS; PATHOGENESIS; HYPERPLASIA;
D O I：
10.3389/fphar.2021.655101
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects 1% of the population. CS-semi5 is a semisynthetic chondroitin sulfate. In this study, CS-semi5 was shown to have positive effects on a model of collagen-induced arthritis (CIA). CS-semi5 treatment had obvious effects on weight loss and paw swelling in CIA mice. Post-treatment analysis revealed that CS-semi5 alleviated three main pathologies (i.e., synovial inflammation, cartilage erosion and bone loss) in a dose-dependent manner. Further study showed that CS-semi5 could effectively reduce TNF-alpha and IL-1 beta production in activated macrophages via the NF-kappa B pathway. CS-semi5 also blocked RANKL-trigged osteoclast differentiation from macrophages. Therefore, CS-semi5 may effectively ameliorate synovial inflammation, cartilage erosion and bone loss in RA through NF-kappa B deactivation.
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页数：14
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