Cardiorespiratory fitness in early-stage Alzheimer disease

被引:46
|
作者
Burns, Jeffrey M. [1 ]
Mayo, Matthew S. [2 ]
Anderson, Heather S. [1 ]
Smith, Holly J. [2 ]
Donnelly, Joseph E. [3 ,4 ]
机构
[1] Univ Kansas, Sch Med, Dept Neurol, Kansas City, KS 66160 USA
[2] Univ Kansas, Sch Med, Dept Biostat, Kansas City, KS 66160 USA
[3] Univ Kansas, Energy Balance Lab, Lawrence, KS 66045 USA
[4] Univ Kansas, Ctr Phys Activ, Lawrence, KS 66045 USA
来源
ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2008年 / 22卷 / 01期
关键词
Alzheimer disease; cardiorespiratory fitness; physical activity; HEALTHY OLDER-ADULTS; PHYSICAL-ACTIVITY; COGNITIVE FUNCTION; ELDERLY PERSONS; WEIGHT-LOSS; INCIDENT DEMENTIA; BODY-COMPOSITION; BLOOD-PRESSURE; TREADMILL TEST; TASK-FORCE;
D O I
10.1097/WAD.0b013e31815a9ddc
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
There is an increasing interest in exercise and fitness in Alzheimer disease (AD) given evidence suggesting a role in the maintenance of cognitive health. There is, however, little data on the objective measure of cardiorespiratory fitness in individuals with AD. Thus, we assessed cardiorespiratory fitness in early AD and its relationship with physical activity levels, health markers, and cognitive performance in nondemented (Clinical Dementia Rating 0, n = 31) and early-stage AD (Clinical Dementia Rating 0.5 and 1, n = 31) participants. Cardiorespiratory fitness was assessed with maximal exercise testing to determine peak oxygen consumption (Vo(2)(peak)). Additionally, dual emission x-ray absorptiometry scanning for body composition and glucose tolerance tests were conducted. Despite reductions in physical performance and habitual physical activity levels in early AD, cardiorespiratory fitness (VO2peak) was comparable in the 2 groups (19.8 in early AD vs. 21.2mL/ kg/min in nondemented, P = 0.26). AD participants performed well on treadmill tests with similar levels of perceived exertion, maximal heart rate, and respiratory exchange ratio compared with nondemented individuals. After controlling for age and sex, VO2peak was associated with a beneficial glucoregulatory profile and inversely associated with percent body fat, body mass index, and triglycerides. A relationship between cognitive performance measures and VO2peak was not apparent. These results suggest that individuals in the early stages of AD have the capacity for maximal exercise testing and have comparable levels of cardiorespiratory fitness as nondemented individuals. Reduced physical activity associated with early AD underscores the need for further defining the role of exercise as a potential therapeutic intervention in the early stages of AD.
引用
收藏
页码:39 / 46
页数:8
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