New Biguanides as Anti-Diabetic Agents, Part II: Synthesis and Anti-Diabetic Properties Evaluation of 1-Arylamidebiguanide Derivatives as Agents of Insulin Resistant Type II Diabetes

被引：6
|
作者：
Basyouni, Wahid M. [1 ]
Abbas, Samir Y. [1 ]
El Shehry, Mohamed F. [2 ]
El-Bayouki, Khairy A. M. [1 ]
Aly, Hanan F. [3 ]
Arafa, Azza [3 ]
Soliman, Mahmoud S. [3 ]
机构：
[1] Natl Res Ctr, Dept Organometall & Organometalloid Chem, Cairo 12622, Egypt
[2] Natl Res Ctr, Dept Pesticide Chem, Cairo, Egypt
[3] Natl Res Ctr, Dept Therapeut Chem, Cairo, Egypt
来源：
ARCHIV DER PHARMAZIE | 2017年 / 350卷 / 11期
关键词：
Anti-diabetic drug; Biguanides; Diabetes mellitus; Metformin; COLORIMETRIC METHOD; SERUM; GUANYLUREAS; PEROXIDE; MELLITUS;
D O I：
10.1002/ardp.201700183
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
New 1-arylamidebiguanide hydrochloride salts were synthesized via reaction of hydrazide derivatives with dicyandiamide in acidic medium. The structure of the obtained derivatives was characterized by spectroscopic and elemental analysis tools. The anti-diabetic properties of the synthesized compounds were determined. Oral treatment of hyperglycemic rats with the synthesized biguanide derivatives showed a significant decrease of the elevated glucose in comparison with the anti-diabetic standard drug, metformin. The effects of the synthesized biguanide derivatives on the diabetic properties regarding liver function enzyme activities (AST, ALT, and ALP), lipid profiles (TC, TG, and TL), lipid peroxide, and nitrous oxide as well as histopathological characteristics were investigated and discussed.
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页数：9
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