Comprehensive profiling and characterization of chemical constituents of rhizome of Anemarrhena asphodeloides Bge

被引:46
|
作者
Ji, De [1 ,2 ]
Huang, Zi-yan [1 ]
Fei, Cheng-hao [1 ,2 ]
Xue, Wei-wei [3 ]
Lu, Tu-lin [1 ,2 ]
机构
[1] Nanjing Univ Chinese Med, Coll Pharm, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Chinese Med, Key Res Lab Chinese Med Proc Jiangsu Prov, Nanjing 210023, Jiangsu, Peoples R China
[3] Jiangsu Prov Hosp TCM, Oncol Dept, 155 Hanzhong Rd, Nanjing 210029, Jiangsu, Peoples R China
来源
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2017年 / 1060卷
基金
中国国家自然科学基金;
关键词
Anemarrhena asphodeloides Bge; Cyclic peptides; Xanthones; Steroidal saponins; UHPLC-QTOF-MS; TIMOSAPONIN B-II; PERFORMANCE LIQUID-CHROMATOGRAPHY; BENZOPHENONE C-GLUCOSIDES; STEROIDAL SAPONINS; INSULIN-RESISTANCE; MASS-SPECTROMETRY; ELECTROSPRAY-IONIZATION; PHENOLIC-COMPOUNDS; QTOF MS; IDENTIFICATION;
D O I
10.1016/j.jchromb.2017.06.032
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The rhizome of Anemarrhena asphodeloides Bge. is commonly used as an herbal medicine in China. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS) was used, in both negative and positive ion modes, to comprehensively analyze the chemical constituents of A. asphodeloides. From the intact precursor ions, MS/MS fragmentation information, and previous reports, we identified 89 compounds. These compounds included 8 cyclic peptides, 11 flavones (9 xanthones), 45 steroidal saponins, 15 fatty acids, 3 lignans, and 7 other compounds. Dimer xanthones and cyclic peptides are reported for the first time in A. asphodeloides. The analytical method we have developed is simple, reliable, and effective. The results provide comprehensive information on the metabolite profile of A. asphodeloides, which may benefit the quality control and further utilization of A. asphodeloides.
引用
收藏
页码:355 / 366
页数:12
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