Anti-inflammatory Activity of Abelmoschus manihot Extracts

The present study was carried out to evaluate the anti-inflammatory activity of the petroleum ether and methanol extract of Abelmoschus manihot (Malvaceae) woody stems using paw edema model The air-dried, powdered woody stems (900 g) were extracted over Soxhlet with petroleum ether and methanol The crude dried petroleum ether (12 g) and methanol (18 g) extracts was prepared at the doses of 100, 200 and 400 mg kg(-1) and evaluated for anti-inflammatory using the carrageenan and histamine-induced paw edema test The results obtained indicate that the extracts possessed significant (p<0 01) anti-inflammatory activity, which was found to be dose-dependent This study showed that the petroleum ether and methanol extracts of Abelmoschus manihot woody stems possess potential pharmacological active constituents responsible for inhibition of the inflammation effect