Synthesis of neomycin-DNA/peptide nucleic acid conjugates

被引：26
|
作者：
Charles, I [1 ]
Arya, DP [1 ]
机构：
[1] Clemson Univ, Dept Chem, Med Chem Lab, Clemson, SC 29634 USA
来源：
JOURNAL OF CARBOHYDRATE CHEMISTRY | 2005年 / 24卷 / 02期
关键词：
neomycin; PNA; DNA; neomycin isothiocyanate;
D O I：
10.1081/CAR-200059973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Syntheses of neomycin conjugates of DNA and peptide nucleic acid (PNA) is reported. The DNA and PNA conjugates were prepared by coupling neomycin isothiocyanate with the amino group of DNA/PNA in order to form a thiourea linkage. The use of neomycin isothiocyanate as an electrophilic reagent for a general route to aminoglycoside-coupled nucleic acid biopolymers is described.
引用
收藏
页码：145 / 160
页数：16
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