Synthesis of neomycin-DNA/peptide nucleic acid conjugates

被引：26

作者：

Charles, I ^{[1
]}

Arya, DP ^{[1
]}

机构：

[1] Clemson Univ, Dept Chem, Med Chem Lab, Clemson, SC 29634 USA

来源：

JOURNAL OF CARBOHYDRATE CHEMISTRY | 2005年 / 24卷 / 02期

关键词：

neomycin; PNA; DNA; neomycin isothiocyanate;

D O I：

10.1081/CAR-200059973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Syntheses of neomycin conjugates of DNA and peptide nucleic acid (PNA) is reported. The DNA and PNA conjugates were prepared by coupling neomycin isothiocyanate with the amino group of DNA/PNA in order to form a thiourea linkage. The use of neomycin isothiocyanate as an electrophilic reagent for a general route to aminoglycoside-coupled nucleic acid biopolymers is described.

引用

页码：145 / 160

页数：16

共 50 条

[1] Automated synthesis of peptide nucleic acids and peptide nucleic acid peptide conjugates
Mayfield, LD
Corey, DR
ANALYTICAL BIOCHEMISTRY, 1999, 268 (02) : 401 - 404
[2] Peptide nucleic acid conjugates: Synthesis, properties and applications
Zhilina, ZV
Ziemba, AJ
Ebbinghaus, SW
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2005, 5 (12) : 1119 - 1131
[3] Solid phase synthesis of peptide nucleic acid-peptide conjugates
Mayfield, L
Katipally, R
Simmons, C
Corey, DR
PEPTIDES: FRONTIERS OF PEPTIDES SCIENCE, 1999, : 299 - 300
[4] Facile synthesis of peptide nucleic acids and peptide nucleic acid-peptide conjugates on an automated peptide synthesizer
Joshi, Rajendra
Jha, Deepti
Su, Wu
Engelmann, Joern
JOURNAL OF PEPTIDE SCIENCE, 2011, 17 (01) : 8 - 13
[5] Synthesis of Nucleic Acid-Peptide Conjugates Targeted to Proteins
Erben, Anne
Seitz, Oliver
ISRAEL JOURNAL OF CHEMISTRY, 2011, 51 (8-9) : 876 - 884
[6] Comparative studies on conventional and microwave synthesis of peptide nucleic acid monomers and peptide conjugates
Dzimbova, T.
Guo, X.
Lankmayr, E.
Pajpanova, T.
AMINO ACIDS, 2009, 37 (04) : 764 - 764
[7] An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates
Patil, Nitin A.
Thombare, Varsha J.
Li, Rong
He, Xiaoji
Lu, Jing
Yu, Heidi H.
Wickremasinghe, Hasini
Pamulapati, Kavya
Azad, Mohammad A. K.
Velkov, Tony
Roberts, Kade D.
Li, Jian
FRONTIERS IN CHEMISTRY, 2022, 10
[8] Peptide nucleic acid-nanodiamonds: covalent and stable conjugates for DNA targeting
Gaillard, Claire
Girard, Hugues A.
Falck, Caroline
Paget, Vincent
Simic, Vesna
Ugolin, Nicolas
Bergonzo, Philippe
Chevillard, Sylvie
Arnault, Jean Charles
RSC ADVANCES, 2014, 4 (07) : 3566 - 3572
[9] Inhibiting gene expression with peptide nucleic acid (PNA)-peptide conjugates that target chromosomal DNA
Hu, Jiaxin
Corey, David R.
BIOCHEMISTRY, 2007, 46 (25) : 7581 - 7589
[10] Synthesis and properties of ester-linked peptide nucleic acid prodrug conjugates
Bendifallah, N
Kristensen, E
Dahl, O
Koppelhus, U
Nielsen, PE
BIOCONJUGATE CHEMISTRY, 2003, 14 (03) : 588 - 592

← 1 2 3 4 5 →