机构:
European Inst Oncol, Div Epidemiol & Biostat, I-120141 Milan, ItalyEuropean Inst Oncol, Div Epidemiol & Biostat, I-120141 Milan, Italy
d'Onofrio, Alberto
[1
]
机构:
[1] European Inst Oncol, Div Epidemiol & Biostat, I-120141 Milan, Italy
来源:
PHYSICAL REVIEW E
|
2007年
/
76卷
/
03期
关键词:
D O I:
10.1103/PhysRevE.76.031920
中图分类号:
O35 [流体力学];
O53 [等离子体物理学];
学科分类号:
070204 ;
080103 ;
080704 ;
摘要:
We deal with a biophysical description of antitumor antiangiogenic therapies. In particular, by means of some simple models, we study the possible effects of the delay between the drug consumption by endothelial cells and their death on the outcome of the therapy. We have found that this time lag implies an increase in the minimal dose guaranteeing tumor eradication and, if the delay is greater than a meaningful threshold, it may preclude the total regression. These results might be of interest in better understanding the causes underlying the contradictory literature on the clinical trials of antiangiogenic therapies.
机构:
Kanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Yano, Seiji
Li, Qi
论文数: 0引用数: 0
h-index: 0
机构:
Kanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Li, Qi
Wang, Wei
论文数: 0引用数: 0
h-index: 0
机构:
Kanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Wang, Wei
论文数: 引用数:
h-index:
机构:
Yamada, Tadaaki
Takeuchi, Shinji
论文数: 0引用数: 0
h-index: 0
机构:
Kanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Takeuchi, Shinji
Nakataki, Emiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokushima, Grad Sch, Dept Resp Med & Rheumatol, Tokushima 7708503, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Nakataki, Emiko
论文数: 引用数:
h-index:
机构:
Ogino, Hirokazu
Goto, Hisatsugu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokushima, Grad Sch, Dept Resp Med & Rheumatol, Tokushima 7708503, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Goto, Hisatsugu
Nishioka, Yasuhiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokushima, Grad Sch, Dept Resp Med & Rheumatol, Tokushima 7708503, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Nishioka, Yasuhiko
Sone, Saburo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokushima, Grad Sch, Dept Resp Med & Rheumatol, Tokushima 7708503, JapanKanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa 9200934, Japan
Sone, Saburo
FRONTIERS IN BIOSCIENCE-LANDMARK,
2011,
16
: 740
-
748
机构:
Brown Univ, Women & Infants Hosp Rhode Isl, Warren Alpert Med Sch, Program Womens Oncol, 101 Dudley Str, Providence, RI 02905 USABrown Univ, Women & Infants Hosp Rhode Isl, Warren Alpert Med Sch, Program Womens Oncol, 101 Dudley Str, Providence, RI 02905 USA
Stuckey, Ashley
Dizon, Don S.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Women & Infants Hosp Rhode Isl, Warren Alpert Med Sch, Program Womens Oncol, 101 Dudley Str, Providence, RI 02905 USABrown Univ, Women & Infants Hosp Rhode Isl, Warren Alpert Med Sch, Program Womens Oncol, 101 Dudley Str, Providence, RI 02905 USA
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA
Sampat, Keeran R.
O'Neil, Bert
论文数: 0引用数: 0
h-index: 0
机构:
Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USAUniv N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA