Rapidly acting antitumoral antiangiogenic therapies

被引:15
|
作者
d'Onofrio, Alberto [1 ]
机构
[1] European Inst Oncol, Div Epidemiol & Biostat, I-120141 Milan, Italy
来源
PHYSICAL REVIEW E | 2007年 / 76卷 / 03期
关键词
D O I
10.1103/PhysRevE.76.031920
中图分类号
O35 [流体力学]; O53 [等离子体物理学];
学科分类号
070204 ; 080103 ; 080704 ;
摘要
We deal with a biophysical description of antitumor antiangiogenic therapies. In particular, by means of some simple models, we study the possible effects of the delay between the drug consumption by endothelial cells and their death on the outcome of the therapy. We have found that this time lag implies an increase in the minimal dose guaranteeing tumor eradication and, if the delay is greater than a meaningful threshold, it may preclude the total regression. These results might be of interest in better understanding the causes underlying the contradictory literature on the clinical trials of antiangiogenic therapies.
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页数:7
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