SYNTHESIS, ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES OF NOVEL THIAZOLIDINYL SULFONAMIDES OF QUINAZOLIN-4(3H)ONES

被引：6
|
作者：
Patel, N. B. [1 ]
Patel, V. N. [1 ]
机构：
[1] Veer Narmad S Gujarat Univ, Dept Chem, Surat 395007, India
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2010年 / 44卷 / 08期
关键词：
2,3-DIARYL-1,3-THIAZOLIDIN-4-ONES;
D O I：
10.1007/s11094-010-0486-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Some novel derivatives of quinazolinone including 2-[2-(2, 6-dichlorophenyl) amino]phenylmethyl-3-{4-[2( substituted phenyl)-4-oxo-thiazolidin-3-yl]phenylsulfonamido-1-yl}-6-bromoquinazolin-4(3H)ones (4a - 4l) were prepared from 2-[2-(2, 6-dichlorophenyl) amino]phenylmethyl-3-{[4-(N-substituted arylidene)phenyl]sulfonamide-1-yl}-6-bromo quinazolin-4(3H)ones (3a - 3l). Twenty four synthesized compounds were screened in vitro for their antibacterial and antifungal activities. Minimum inhibitory concentration (MIC) values of all the twenty four compounds were determined. Some of these compounds exhibited significant antimicrobial activity.
引用
收藏
页码：438 / 445
页数：8
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