CST Meets Shelterin to Keep Telomeres in Check

被引：115
|
作者：
Giraud-Panis, Marie-Josephe [1 ,2 ,3 ]
Teixeira, M. Teresa [3 ]
Geli, Vincent [4 ]
Gilson, Eric [1 ,2 ,3 ,5 ]
机构：
[1] Univ Nice, Lab Biol & Pathol Genomes, CNRS, INSERM,UMR 6267,U998,Fac Med, F-06107 Nice 2, France
[2] Univ Lyon, Lab Joliot Curie, Ecole Normale Super Lyon, F-69364 Lyon, France
[3] Univ Lyon, Lab Biol Mol Cellule, Ecole Normale Super Lyon, CNRS,UMR 5239, F-69364 Lyon, France
[4] CNRS, Instabilite Genome & Cancerogenese, CNRS, F-13402 Marseille 20, France
[5] Ctr Hosp Univ Nice, Dept Med Genet, Archet Hosp 2, F-06202 Nice, France
来源：
MOLECULAR CELL | 2010年 / 39卷 / 05期
关键词：
SINGLE-STRANDED-DNA; CHROMOSOME END-PROTECTION; POLYMERASE-ALPHA-PRIMASE; SACCHAROMYCES-CEREVISIAE; BINDING-PROTEIN; YEAST TELOMERASE; OB-FOLD; LENGTH REGULATION; MAMMALIAN TELOMERES; ACCESSORY PROTEIN;
D O I：
10.1016/j.molcel.2010.08.024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Telomere protection in budding yeast requires the heterotrimer named CST (for Cdc13-Stn1-Ten1). Recent data show that CST components are conserved and required for telomere stability in a wide range of eukaryotes, even those utilizing the shelterin complex to protect their telomeres. A common function of these proteins might be to stimulate priming at the C-strand gap that remains after telomerase elongation, replication termination, and terminal processing. In light of the budding yeast situation, another conserved function of CST might well be the regulation of telomerase. The cohabitation at telomeres of CST and shelterin components highlights the complexity of telomere biology.
引用
收藏
页码：665 / 676
页数：12
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