Eight-year survival of a recurrent glioblastoma patient treated with molecularly tailored therapy: a case report

被引：2
|
作者：
D'Alessandris, Quintino Giorgio [1 ]
Montano, Nicola [1 ]
Martini, Maurizio [2 ,3 ]
Cenci, Tonia [2 ]
Lauretti, Liverana [1 ,3 ]
Stumpo, Vittorio [3 ]
Pignotti, Fabrizio [1 ,3 ]
Olivi, Alessandro [1 ,3 ]
Fernandez, Eduardo [1 ,3 ]
Larocca, Luigi Maria [2 ,3 ]
Pallini, Roberto [1 ,3 ]
机构：
[1] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Neurosurg, Largo Agostino Gemelli 8, I-00168 Rome, Italy
[2] Fdn Policlin Univ Agostino Gemelli IRCCS, Dept Pathol, Largo Agostino Gemelli 8, I-00168 Rome, Italy
[3] Univ Cattolica Sacro Cuore, Rome, Italy
来源：
ACTA NEUROCHIRURGICA | 2018年 / 160卷 / 12期
关键词：
Glioblastoma; Targeted therapy; Tailored therapy; Bevacizumab; Erlotinib; BEVACIZUMAB; TEMOZOLOMIDE; RADIOTHERAPY; ERLOTINIB; EGFRVIII; AVAGLIO; TRIAL;
D O I：
10.1007/s00701-018-3697-3
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Treatment options for recurrent glioblastoma are scarce; targeted therapy trials were disappointing, probably due to enrollment of patients without molecular selection. We treated with bevacizumab and erlotinib a 66-year-old male suffering from recurrent glioblastoma, IDH-wildtype and MGMT unmethylated, after three neurosurgeries. Treatment was tailored on molecular profile of recurrent tumornamely, EGFRvIII positivity, VEGF overexpression, normal PTEN, low total VEGF and VEGF-121 mRNAand resulted in complete, exceptionally durable response (51-month progression-free survival). Notably, histology of further recurrence after therapy was reminiscent of sarcoma. We suggest a thorough molecular screening for personalization of targeted therapy in recurrent glioblastoma.
引用
收藏
页码：2387 / 2391
页数：5
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