Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood

被引:8
|
作者
Tiszlavicz, L
Kapin, M
Várkonyi, A
Lörincz, A
Bartyik, K
Várkonyi, T
机构
[1] Univ Szeged, Fac Med, Dept Pathol, H-6724 Szeged, Hungary
[2] Univ Szeged, Fac Med, Dept Paediat, H-6724 Szeged, Hungary
[3] Rethy Pal Cty Hosp Bekescsaba, Dept Internal Med, Bekescsaba, Hungary
关键词
colorectal carcinoma; childhood; p53; overexpression; colonic Crohn disease;
D O I
10.1007/s004310000699
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Colorectal carcinoma rarely affects children and has a dismal prognosis with 5-year survival rates as low as 2.5%-7% despite apparently radical surgery. Here we report the case of an adenocarcinoma of the sigmoid colon in a 15-year-old girl preceded by uncertain abdominal complaints of 5 years' duration. Pathological work-up revealed a tumour with lymph node metastases (pT3N1). Immunohistochemical evidence of p53 overexpression by the tumour cells raised the suspicion of an underlying Li-Fraumeni syndrome. In addition, there were aphthoid ulceration, fissuration of the non-tumorous mucosa, along with a mixed transmural infiltrate composed of macrophages, eosinophils and non-typical giant cells, which were compatible with simultaneous Crohn's disease. Anamnestic data concerning the occurrence of idiopathic inflammatory bowel disease or colorectal carcinoma in the patient's relatives were non-contributory. The present results suggest a possible relationship between Crohn's disease and colon cancer due to the defective p53 gene product.
引用
收藏
页码:168 / 172
页数:5
相关论文
共 50 条
  • [21] Small bowel adenocarcinoma in Crohn's disease
    Feldstein, Richard C.
    Sood, Shivani
    Katz, Seymour
    INFLAMMATORY BOWEL DISEASES, 2008, 14 (08) : 1154 - 1157
  • [22] Crohn's Disease of the Colon, Rectum, and Anus
    Harb, William J.
    SURGICAL CLINICS OF NORTH AMERICA, 2015, 95 (06) : 1195 - +
  • [23] Mucinous adenocarcinomas of the colon in Crohn's disease
    Birkenmeier, G
    Goullon, JE
    Niedobitek, F
    CHIRURG, 1997, 68 (01): : 51 - 56
  • [24] Small Bowel Adenocarcinoma in Crohn’s Disease
    Maria Widmar
    Alexander J. Greenstein
    David B. Sachar
    Noam Harpaz
    Joel J. Bauer
    Adrian J. Greenstein
    Journal of Gastrointestinal Surgery, 2011, 15 : 797 - 802
  • [25] Adenocarcinoma complicating Crohn's disease of the duodenum
    El Mansari, O
    Parc, Y
    Lamy, P
    Parc, R
    Tiret, E
    Beaugerie, L
    EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, 2001, 13 (10) : 1259 - 1260
  • [26] Primary Adenocarcinoma of an Ileostomy in Crohn's Disease
    Liu, Kevin
    Prasad, Meena A.
    Lo, Amy
    Bellaguarda, Emanuelle
    Strong, Scott
    Hanauer, Stephen B.
    ACG CASE REPORTS JOURNAL, 2016, 3 (04)
  • [27] Adenocarcinoma of the small intestine in Crohn's disease
    de la Cruz Cuadrado, Cristina
    Lopez-Fernandez, Jose
    Garcia Plaza, Gabriel
    Montecino Romanini, Carolina
    Hernandez Hernandez, Juan Ramon
    REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS, 2021, 113 (11) : 798 - 798
  • [28] Social implications of childhood Crohn's disease
    Moody, G
    Eaden, JA
    Mayberry, JF
    JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 1999, 28 (04): : S43 - S45
  • [29] Nutritional treatment in childhood Crohn's disease
    Bocquet, A
    Bresson, JL
    Briend, A
    Chouraqui, JP
    Darmaun, D
    Dupont, C
    Frelut, ML
    Ghisolfi, J
    Girardet, JP
    Goulet, O
    Putet, G
    Rieu, D
    Rigo, J
    Turck, D
    Vidailhet, M
    ARCHIVES DE PEDIATRIE, 2005, 12 (08): : 1255 - 1266
  • [30] Social implications of childhood Crohn's disease
    Moody, GA
    Eaden, JA
    Mayberry, JF
    GUT, 1997, 40 : W86 - W86