Adenocarcinoma of the colon developing on the basis of Crohn's disease in childhood

被引:8
|
作者
Tiszlavicz, L
Kapin, M
Várkonyi, A
Lörincz, A
Bartyik, K
Várkonyi, T
机构
[1] Univ Szeged, Fac Med, Dept Pathol, H-6724 Szeged, Hungary
[2] Univ Szeged, Fac Med, Dept Paediat, H-6724 Szeged, Hungary
[3] Rethy Pal Cty Hosp Bekescsaba, Dept Internal Med, Bekescsaba, Hungary
关键词
colorectal carcinoma; childhood; p53; overexpression; colonic Crohn disease;
D O I
10.1007/s004310000699
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Colorectal carcinoma rarely affects children and has a dismal prognosis with 5-year survival rates as low as 2.5%-7% despite apparently radical surgery. Here we report the case of an adenocarcinoma of the sigmoid colon in a 15-year-old girl preceded by uncertain abdominal complaints of 5 years' duration. Pathological work-up revealed a tumour with lymph node metastases (pT3N1). Immunohistochemical evidence of p53 overexpression by the tumour cells raised the suspicion of an underlying Li-Fraumeni syndrome. In addition, there were aphthoid ulceration, fissuration of the non-tumorous mucosa, along with a mixed transmural infiltrate composed of macrophages, eosinophils and non-typical giant cells, which were compatible with simultaneous Crohn's disease. Anamnestic data concerning the occurrence of idiopathic inflammatory bowel disease or colorectal carcinoma in the patient's relatives were non-contributory. The present results suggest a possible relationship between Crohn's disease and colon cancer due to the defective p53 gene product.
引用
收藏
页码:168 / 172
页数:5
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