Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients

被引：10

作者：

Diaz-Morales, Noelia ^{[1
]}

Rovira-Llopis, Susana ^{[1
,2
]}

Escribano-Lopez, Irene ^{[1
]}

Banuls, Celia ^{[1
,2
]}

Lopez-Domenech, Sandra ^{[1
]}

Falcon, Rosa ^{[1
,2
]}

de Maranon, Arantxa Martinez ^{[1
]}

Sola, Eva ^{[1
,2
]}

Jover, Ana ^{[1
]}

Roldan, Ildefonso ^{[4
]}

Diez, Jose L. ^{[5
]}

Rocha, Milagros ^{[1
,2
,3
]}

Hernandez-Mijares, Antonio ^{[1
,2
,6
]}

Victor, Victor M. ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Dr Peset, Serv Endocrinol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[2] Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain

[3] Univ Valencia, CIBERehd, Dept Physiol & Pharmacol, Valencia, Spain

[4] Univ Hosp Dr Peset, Serv Cardiol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[5] Univ Hosp Dr Peset, Serv Haematol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[6] Univ Valencia, Dept Med, Valencia, Spain

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 18期

关键词：

Antioxidants; Mitochondria; Muscle; Oxidative stress; Type; 2; diabetes; HIGH-FAT DIET; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; MOLECULAR-MECHANISMS; PROTEIN-SYNTHESIS; GENE-EXPRESSION; HEART-FAILURE; ER STRESS; GLUCOSE; PHOSPHORYLATION;

D O I：

10.2174/1381612822666160217142949

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.

引用

页码：2650 / 2656

页数：7

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