Role of Oxidative Stress and Mitochondrial Dysfunction in Skeletal Muscle in Type 2 Diabetic Patients

被引：10

作者：

Diaz-Morales, Noelia ^{[1
]}

Rovira-Llopis, Susana ^{[1
,2
]}

Escribano-Lopez, Irene ^{[1
]}

Banuls, Celia ^{[1
,2
]}

Lopez-Domenech, Sandra ^{[1
]}

Falcon, Rosa ^{[1
,2
]}

de Maranon, Arantxa Martinez ^{[1
]}

Sola, Eva ^{[1
,2
]}

Jover, Ana ^{[1
]}

Roldan, Ildefonso ^{[4
]}

Diez, Jose L. ^{[5
]}

Rocha, Milagros ^{[1
,2
,3
]}

Hernandez-Mijares, Antonio ^{[1
,2
,6
]}

Victor, Victor M. ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Dr Peset, Serv Endocrinol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[2] Univ Valencia, Inst Hlth Res INCLIVA, Valencia, Spain

[3] Univ Valencia, CIBERehd, Dept Physiol & Pharmacol, Valencia, Spain

[4] Univ Hosp Dr Peset, Serv Cardiol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[5] Univ Hosp Dr Peset, Serv Haematol, Fdn Promot Hlth & Biomed Res Valencian Reg FISABI, Valencia 46017, Spain

[6] Univ Valencia, Dept Med, Valencia, Spain

来源：

CURRENT PHARMACEUTICAL DESIGN | 2016年 / 22卷 / 18期

关键词：

Antioxidants; Mitochondria; Muscle; Oxidative stress; Type; 2; diabetes; HIGH-FAT DIET; INSULIN-RESISTANCE; MYOCARDIAL-INFARCTION; MOLECULAR-MECHANISMS; PROTEIN-SYNTHESIS; GENE-EXPRESSION; HEART-FAILURE; ER STRESS; GLUCOSE; PHOSPHORYLATION;

D O I：

10.2174/1381612822666160217142949

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Type 2 diabetes can increase the risk of skeletal muscle dysfunction and, consequently, that of cardiovascular diseases, including coronary artery disease and stroke. It is also related to a reduced capacity for exercise, but the underlying mechanism is only partially understood. There are several factors that contribute to the development of skeletal muscle dysfunction, of which oxidative stress and mitochondrial dysfunction are among the most important. This review discusses the role of oxidative stress in the development and progression of skeletal and cardiac dysfunction associated with diabetes. It also provides an overview of the potential actions of antioxidants in general and mitochondria-targeted antioxidants in particular in the treatment of muscle dysfunction in type 2 diabetes.

引用

页码：2650 / 2656

页数：7

共 50 条

[1] Mitochondrial Dysfunction in Type 2 Diabetic Skeletal Muscle Cells
Castaneda, Diana L.
Yamazaki, Katrina
FASEB JOURNAL, 2018, 32 (01):
[2] The role of mitochondrial DNA damage at skeletal muscle oxidative stress on the development of type 2 diabetes
dos Santos, Julia Matzenbacher
de Oliveira, Denise Silva
Moreli, Marcos Lazaro
Benite-Ribeiro, Sandra Aparecida
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2018, 449 (1-2) : 251 - 255
[3] The role of mitochondrial DNA damage at skeletal muscle oxidative stress on the development of type 2 diabetes
Julia Matzenbacher dos Santos
Denise Silva de Oliveira
Marcos Lazaro Moreli
Sandra Aparecida Benite-Ribeiro
Molecular and Cellular Biochemistry, 2018, 449 : 251 - 255
[4] Skeletal muscle perfusion and mitochondrial oxidative activity in type 2 diabetic patients according to microangiopathic complications
Chiheb, S.
Duteil, S.
Cosson, E.
Wary, C.
Paries, J.
Monnet, A.
Chanu, B.
Mesangeau, D.
Carlier, P.
Valensi, P.
DIABETOLOGIA, 2012, 55 : S493 - S493
[5] Oxidative stress in skeletal muscle impairs mitochondrial respiration and limits exercise capacity in type 2 diabetic mice
Yokota, Takashi
Kinugawa, Shintaro
Hirabayashi, Kagami
Matsushima, Shouji
Inoue, Naoki
Ohta, Yukihiro
Hamaguchi, Sanae
Sobirin, Mochamad A.
Ono, Taisuke
Suga, Tadashi
Kuroda, Satoshi
Tanaka, Shinya
Terasaki, Fumio
Okita, Koichi
Tsutsui, Hiroyuki
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2009, 297 (03): : H1069 - H1077
[6] Skeletal muscle mitochondrial dysfunction in Type 2 diabetes
Pazderska, Agnieszka
Wanic, Krzysztof
Nolan, John J.
EXPERT REVIEW OF ENDOCRINOLOGY & METABOLISM, 2010, 5 (04) : 475 - 477
[7] Mitochondrial function in skeletal muscle of arm and leg of type 2 diabetic patients
Rabol, R.
Hojberg, P. V.
Haugaard, S. B.
Almdal, T.
Madsbad, S.
Dela, F.
DIABETOLOGIA, 2007, 50 : S312 - S312
[8] Oxidative Stress and Mitochondrial Dysfunction in Type 2 Diabetes
Victor, Victor M.
Rocha, Milagros
Herance, Raul
Hernandez-Mijares, Antonio
CURRENT PHARMACEUTICAL DESIGN, 2011, 17 (36) : 3947 - 3958
[9] Physical activity and endothelial dysfunction in type 2 diabetic patients: the role of nitric oxide and oxidative stress
Brinkmann, Christian
Schwinger, Robert H. G.
Brixius, Klara
WIENER MEDIZINISCHE WOCHENSCHRIFT, 2011, 161 (11-12) : 305 - 314
[10] Mitochondrial stress and metabolic dysfunction in skeletal muscle
Muoio, Deborah
FASEB JOURNAL, 2012, 26

← 1 2 3 4 5 →