Prediction of transition from cognitive impairment to senile dementia: a prospective, longitudinal study

被引:95
|
作者
Artero, S
Tierney, MC
Touchon, J
Ritchie, K
机构
[1] Hop Colombiere, INSERM, EMI Epidemiol Nervous Syst Pathol 9930, French Natl Inst Hlth & Med Res, F-34093 Montpellier 5, France
[2] Univ Toronto, Dept Family & Community Med, Sunnybrook & Womens Coll Hlth Sci Ctr, Toronto, ON M5S 1A1, Canada
关键词
Alzheimer's disease; cognition; mild cognitive impairment;
D O I
10.1034/j.1600-0447.2003.00081.x
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: The purpose of this investigation was to replicate the statistical approach used in a previous investigation (Toronto study) within a French population to determine the best predictive model for Alzheimer's disease (AD). Method: Data from neuropsychological tests from two prospective studies were entered into a regression model. Results: Replication of the statistical approach in the Montpellier sample produced a three-test model with a specificity of 99% and sensitivity of 73%. This model consisted of a delayed auditory verbal recall test, a construction test, a category fluency test and provides probability estimates for the transition to dementia in individual cases. Conclusion: The models derived from these two longitudinal studies provide an empirical basis for the selection of tests for the definition of mild cognitive impairment of the Alzheimer type (MCI-A). The small set of tests derived are suitable for use in general practice.
引用
收藏
页码:390 / 393
页数:4
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