Gene and protein expression of brain-derived neurotrophic factor and TrkB in bone and cartilage

被引：60

作者：

Yamashiro, T ^{[1
]}

Fukunaga, T ^{[1
]}

Yamashita, K ^{[1
]}

Kobashi, N ^{[1
]}

Takano-Yamamoto, T ^{[1
]}

机构：

[1] Okayama Univ, Sch Dent, Dept Orthodont, Okayama 7008525, Japan

来源：

BONE | 2001年 / 28卷 / 04期

关键词：

bone-derived neurotrophic factor (BDNF); TrkB; in situ hybridization; immunohistochemistry; osteoblast; chondrocyte;

D O I：

10.1016/S8756-3282(01)00405-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Gene and protein expressions of brain-derived neurotrophic factor (BDNF) and TrkB, the high-affinity receptor of BDNF, were investigated in the femur and mandibular condyle of rats by in situ hybridization and immunohistochemistry. BDNF and TrkB mRNA showed overlapped expression in chondrocytes in proliferating and mature zones of the epiphyseal growth plate cartilage and mandibular condylar cartilage, and in cuboidal-shaped active osteoblasts at the site of endochondral and intramembranous ossification and in trabecular bone. Expression of BDNF protein also showed a similar localization. The present study suggests that BDNF may participate in regulating the development and remodeling of bony tissue in the developing rat. (Bone 28:404-409; 2001) (C) 2001 by Elsevier Science Inc, All rights reserved.

引用

页码：404 / 409

页数：6

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