Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA

被引：32

作者：

Miyatake, R ^{[1
]}

Furukawa, A ^{[1
]}

Matsushita, M ^{[1
]}

Iwahashi, K ^{[1
]}

Nakamura, K ^{[1
]}

Ichikawa, Y ^{[1
]}

Suwaki, H ^{[1
]}

机构：

[1] KAGAWA MED UNIV,DEPT BIOCHEM,MIKI,KAGAWA 76107,JAPAN

来源：

FEBS LETTERS | 1996年 / 395卷 / 2-3期

关键词：

ryanodine receptor; calcium release channel; mouse brain; alternative splicing; RT-PCR;

D O I：

10.1016/0014-5793(96)01022-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We detected alternative splicing of the mouse brain type ryanodine receptor (RyR3) mRNA. The splicing variant,vas located in the transmembrane segment. The non-splicing type (RyR3-II) included a stretch of 341 bp, and that of the 13th codon was stop codon TAA. Reverse transcription-polymerase chain reaction (RT-PCR) analysis shows that RyR3-II mRNA was expressed in various peripheral tissues and brain at all developmental stages. However, interestingly, the splicing type (RyR3-I) mRNA was detected only in the cerebrum. These findings suggest that the splicing variants RyR3-I and RyR3-II may generate functional differences of RyR3 in a tissue-specific manner.

引用

页码：123 / 126

页数：4

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