Metal-free intramolecular hydroarylation of alkynes

被引：11

作者：

Zhang, Chaofeng ^{[1
]}

Lv, Songkui ^{[1
]}

Wang, Yanru ^{[1
]}

Zhang, Jingyi ^{[1
]}

Wang, Xiao-Na ^{[1
]}

Chang, Junbiao ^{[1
]}

机构：

[1] Zhengzhou Univ, Collaborat Innovat Ctr New Drug Res & Safety Eval, Sch Pharmaceut Sci, Key Lab Adv Drug Preparat Technol,Minist Educ, Zhengzhou 450001, Henan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2022年 / 9卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ACID-CATALYZED ALLYLBORATION; C-H BONDS; BRONSTED-ACID; REGIOSELECTIVE SYNTHESIS; 2-NAPHTHOL DERIVATIVES; NATURAL-PRODUCTS; AMINE COMPLEX; GOLD; CYCLOISOMERIZATION; CYCLIZATION;

D O I：

10.1039/d1qo01831k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient metal-free intramolecular hydroarylation reaction of alkynes is described here. A series of aryl and N-group attached alkynes generated the intramolecular hydroarylation products in high yields. In addition to that, less steric hindrance alkynes led to complex mixtures resulting from the formal oxidation and reduction of hydroarylation products. Furthermore, a one-pot synthesis of 4,4 '-disubstituted-1,1 '-binaphthyls is accomplished via a hydroarylation/oxidative coupling protocol.

引用

页码：1300 / 1307

页数：8

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