Boosting the impact of seasonal malaria chemoprevention (SMC) through simultaneous screening and treatment of household members of children receiving SMC in Burkina Faso: a protocol for a randomized open label trial

被引：2

作者：

Sondo, Paul ^{[1
]}

Tahita, Marc Christian ^{[1
]}

Ilboudo, Hamidou ^{[1
]}

Rouamba, Toussaint ^{[1
]}

Derra, Karim ^{[1
]}

Tougri, Gauthier ^{[2
]}

Ouedraogo, Florence ^{[1
]}

Konseibo, Beatrice Marie Adelaide ^{[2
]}

Roamba, Eli ^{[1
]}

Otienoburu, Sabina Dahlstrom ^{[3
,4
,5
]}

Kabore, Berenger ^{[1
]}

Kennon, Kalynn ^{[3
]}

Ouedraogo, Kadija ^{[1
]}

Zongo, Wend-Timbe-Noma Arlette Raissa ^{[1
]}

Bocoum, Fadima Yaya ^{[1
]}

Stepniewska, Kasia ^{[3
,4
,6
]}

Dhorda, Mehul ^{[3
,4
,6
]}

Guerin, Philippe J. ^{[3
,4
,6
]}

Tinto, Halidou ^{[1
]}

机构：

[1] Intitut Rech Siences Sante IRSS, Clin Res Unit Nanoro CRUN, Nanoro, Burkina Faso

[2] Minist Hlth Burkina Faso, Natl Malaria Control Program, Ouagadougou, Burkina Faso

[3] Infect Dis Data Observ IDDO, Oxford, England

[4] Worldwide Antimalarial Resistance Network WWARN, Oxford, England

[5] Johnson C Smith Univ, Coll Stem, Charlotte, NC USA

[6] Univ Oxford, Ctr Trop Med & Global Hlth, Nuffield Dept Med, Oxford, England

来源：

ARCHIVES OF PUBLIC HEALTH | 2022年 / 80卷 / 01期

关键词：

Malaria; Chemoprevention; Plasmodium falciparum; Africa; Burkina Faso; Amodiaquine; Sulfadoxine-pyrimethamine; Dihydro artemisinin Piperaquine; FALCIPARUM; MUTATIONS;

D O I：

10.1186/s13690-022-00800-x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background Plasmodium falciparum malaria remains a major public health concern in sub-Sahara Africa. Seasonal malaria chemoprevention (SMC) with amodiaquine + sulfadoxine-pyrimethamine is one of the most important preventive interventions. Despite its implementation, the burden of malaria is still very high in children under five years old in Burkina Faso, suggesting that the expected impact of this promising strategy might not be attained. Development of innovative strategies to improve the efficacy of these existing malaria control measures is essential. In such context, we postulate that screening and treatment of malaria in household members of children receiving SMC could greatly improve the impact of SMC intervention and reduce malaria transmission in endemic settings. Methods This randomized superiority trial will be carried out in the Nanoro health district, Burkina Faso. The unit of randomisation will be the household and all eligible children from a household will be allocated to the same study group. Households with 3-59 months old children will be assigned to either (i) control group (SMC alone) or (ii) intervention (SMC+ screening of household members with standard Histidin Rich Protein Rapid Diagnostic Test (HRP2-RDT) and treatment if positive). The sample size will be 526 isolated households per arm, i.e., around 1052 children under SMC coverage and an expected 1315 household members. Included children will be followed-up for 24 months to fully cover two consecutive malaria transmission seasons and two SMC cycles. Children will be actively followed-up during the malaria transmission seasons while in the dry seasons the follow-up will be passive. Conclusion The study will respond to a major public health concern by providing evidence of the efficacy of an innovative strategy to boost the impact of SMC intervention.

引用

页数：10

共 21 条

[21] Safety of Seasonal Malaria Chemoprevention (SMC) with Sulfadoxine-Pyrimethamine plus Amodiaquine when Delivered to Children under 10 Years of Age by District Health Services in Senegal: Results from a Stepped-Wedge Cluster Randomized Trial (vol 11, e0162563, 2016)
NDiaye, J. L.
Cisse, B.
Ba, E. H.
Gomis, J. F.
Ndour, C. T.
Molez, J. F.
Fall, F. B.
Sokhna, C.
Faye, B.
Kouevijdin, E.
Niane, F. K.
Cairns, M.
Trape, J. F.
Rogier, C.
Gaye, O.
Greenwood, B. M.
Milligan, P. J. M.
[J]. PLOS ONE, 2016, 11 (12):

← 1 2 3 →