Oxone-Promoted Synthesis of Bis(indolyl)methanes from Arylmethylamines and Indoles

被引：11
|
作者：
Kadu, Vikas D. [1 ]
Patil, Amruta A. [1 ]
Shendage, Prajakta R. [1 ]
机构：
[1] Punyashlok Ahilyadevi Holkar Solapur Univ, Sch Chem Sci, Solapur 413255, Maharashtra, India
来源：
JOURNAL OF MOLECULAR STRUCTURE | 2022年 / 1267卷
关键词：
oxone; indole; benzylamine; bis(indolyl)methanes; arylmethylamines; aerobic; ONE-POT SYNTHESIS; CANCER CELLS; BIS(INDOLE) ALKALOIDS; CARBOXYLIC-ACIDS; BENZYL ALCOHOLS; DERIVATIVES; ACTIVATION; INDOLE-3-CARBINOL; METABOLITE; CHEMISTRY;
D O I：
10.1016/j.molstruc.2022.133502
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An environmentally benign synthesis of 3,3'-bis(indolyl)methanes (BIMs) has been developed from aryl-methylamines and indoles under aerobic condition in presence of oxone. The formation of BIMs using ethanol as a green reaction medium represents a good practical method for synthesis. The good toler-ance was observed towards various functional groups for exploring substrate scope in presence of oxone and the synthesized BIMs afforded in excellent yields up to 94%.(c) 2022 Elsevier B.V. All rights reserved.
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页数：9
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