Kallikrein-Kinin System: A Surgical Perspective in Post-Aprotinin Era

被引：4
|
作者：
Saxena, Pankaj [2 ,3 ,4 ]
Thompson, Philip [3 ,4 ]
d'Udekem, Yves [1 ]
Konstantinov, Igor E. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Melbourne, Royal Childrens Hosp, Cardiac Surg Unit, Parkville, Vic 3052, Australia
[2] Univ Western Australia, Sch Surg, Perth, WA 6009, Australia
[3] Univ Western Australia, Ctr Asthma Allergy & Resp Res, Perth, WA 6009, Australia
[4] Lung Inst Western Australia, Perth, WA 6009, Australia
来源：
JOURNAL OF SURGICAL RESEARCH | 2011年 / 167卷 / 01期
基金：
英国医学研究理事会;
关键词：
Ischemia; preconditioning; kinin; aprotinin; MOLECULAR-WEIGHT KININOGEN; LEFT-VENTRICULAR HYPERTROPHY; MYOCARDIAL INFARCT SIZE; KAPPA-B ACTIVATION; B-1 RECEPTOR GENE; ENDOTHELIAL-CELLS; CONTACT SYSTEM; KINASE PATHWAY; UP-REGULATION; IN-VIVO;
D O I：
10.1016/j.jss.2009.12.020
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Kallikrein-kinin system (KKS) plays an important role in inflammation, ischemia-reperfusion (IR) injury, and development of neoplasia. There is evidence to suggest that KKS plays an important role in organ protection during preconditioning. Aprotinin is a nonspecific serine protease inhibitor, which has been extensively used in cardiac surgery for the control of post operative bleeding. The anti-inflammatory effects of aproprotin are due to its inhibitory effect on the kallikrein-kinin system (KKS). We herein review KKS and its role as applied to the practice of surgery. Crown Copyright (C) 2011 Published by Elsevier Inc. All rights reserved.
引用
收藏
页码：70 / 77
页数：8
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