Brain infarction following 5-fluorouracil and cisplatin therapy

被引:39
|
作者
El Amrani, M
Heinzlef, O
Debroucker, T
Roullet, E
Bousser, MG
Amarenco, P
机构
[1] Hop Lariboisiere, Dept Neurol, Serv Neurol, F-75475 Paris 10, France
[2] Univ Paris 06, Hop St Antoine, Dept Neurol, Paris, France
[3] Univ Paris 06, Hop Tenon, Dept Neurol, Paris, France
[4] Delafontaine Hosp, St Denis, France
关键词
D O I
10.1212/WNL.51.3.899
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Five patients with oropharyngeal cancer treated with 5-fluorouracil and cisplatin had ischemic stroke within 2 to 5 days after the drug infusion. This occurred during the second course of chemotherapy in three patients, and during the third course in two patients. There may be a relation between treatment and brain infarction because 1) there was no other cause identified despite extensive tests, including postmortem examination in one patient; 2) there was a short delay between treatment infusion and stroke; and 3) there was a similar pattern of ischemic stroke after the second or third course of chemotherapy.
引用
收藏
页码:899 / 901
页数:3
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