Synthesis and comparative study on the antibacterial activity organotin(IV) 3-hydroxybenzoate compounds

The synthesis and comparative study on the antibacterial activity of three organotin(IV) compounds, namely dibutyltin(IV) bis-(3-hydroxybenzoate), [Bu2Sn(3-HBz)(2)] (7), diphenyltin(IV) bis-(3-hydroxybenzoate), [Ph2Sn(3-HBz)(2)] (8), and triphenyltin(IV) 3-hydroxybenzoate, [Ph3Sn(3-HBz)] (9) which were prepared by the reaction of dibutyltin(IV) oxide, [Bu2SnO] (4), diphenyltin(IV) dihydroxide, [Ph2Sn(OH)(2)] (5), and triphenyltin(IV) hydroxide, [Ph3SnOH] (6) with 3-hydroxybenzoic acid (3-HBz) has successfully been performed. The characterization of these compounds were done using H-1 and C-13 NMR, IR, UV spectroscopies and their compositions were determined based onmicroanalytical data. Antibacterial activity of these compounds was demonstrated at concentrations of 1.89 x 10(-4), 1.81 x 10(-4), and 1.72 x 10(-4)M, respectively by dilutionmethod against Pseudomonas aeruginosa. Similarly, the compounds were active at concentration of 1.87 x 10(-4), 1.79 x 10(-4), and 1.71 x 10(-4) M, respectively, against Bacillus subtilis. These activities are comparable to that of streptomycin at a concentration of 1.70 x 10(-4) M as a positive control, but the halozone of compounds 7, 8, and 9 were slightly lower than that of streptomycin's halozone. The results obtained suggest that the compounds synthesized have potential as anti-bacterial agents.