Renal Comorbidity After Solid Organ and Stem Cell Transplantation

被引：25

作者：

Clajus, C. ^{[1
]}

Hanke, N. ^{[1
]}

Gottlieb, J. ^{[2
]}

Stadler, M. ^{[3
]}

Weismueller, T. J. ^{[4
]}

Strassburg, C. P. ^{[4
]}

Broecker, V. ^{[5
]}

Bara, C. ^{[6
]}

Lehner, F. ^{[7
]}

Drube, J. ^{[8
]}

Kielstein, J. T. ^{[1
]}

Schwarz, A. ^{[1
]}

Gueler, F. ^{[1
]}

Haller, H. ^{[1
]}

Schiffer, M. ^{[1
]}

机构：

[1] Hannover Med Sch, Div Nephrol & Hypertens, D-3000 Hannover, Germany

[2] Hannover Med Sch, Div Pulmonol, D-3000 Hannover, Germany

[3] Hannover Med Sch, Div Hematol Hemostasis Oncol & Stem Cell Transpla, D-3000 Hannover, Germany

[4] Hannover Med Sch, Div Gastroenterol Hepatol & Endocrinol, D-3000 Hannover, Germany

[5] Hannover Med Sch, Dept Pathol, D-3000 Hannover, Germany

[6] Hannover Med Sch, Dept Cardiac Thorac Transplantat & Vasc Surg, D-3000 Hannover, Germany

[7] Hannover Med Sch, Dept Gen Visceral & Transplantat Surg, D-3000 Hannover, Germany

[8] Hannover Med Sch, Dept Pediat Nephrol, Integrated Res & Treatment Ctr Transplantat IFB T, D-3000 Hannover, Germany

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2012年 / 12卷 / 07期

关键词：

Dialysis; heart transplantation; hemato-poietic stem cell transplantation; kidney transplantation; liver transplantation; lung transplantation; CHRONIC KIDNEY-DISEASE; LIVER-TRANSPLANTATION; CALCINEURIN INHIBITOR; REQUIRING DIALYSIS; CYSTATIN-C; FAILURE; INJURY; PREDICTORS; RECIPIENTS; LUNG;

D O I：

10.1111/j.1600-6143.2012.04047.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

After transplantation of solid organs or hematopoietic stem cells, a significant acute decrease in renal function occurs in the majority of patients. Depending on the degree of kidney injury, a large number of patients develop chronic kidney disease (CKD) and some develop end-stage renal disease requiring renal replacement therapy. The incidence varies depending on the transplanted organ, but important risk factors for the development of CKD are preexisting renal disease, hepatitis C, diabetes, hypertension, age, sex, posttransplant acute kidney injury and thrombotic microangiopathy. This review article focuses on the risk factors of posttransplant chronic kidney disease after organ transplantation, considering the current literature and integrates the incidence and the associated mortality rates of acute and chronic kidney disease. Furthermore, we introduce the RECAST (REnal Comorbidity After Solid organ and hematopoietic stem cell Transplantation) registry.

引用

页码：1691 / 1699

页数：9

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