Association of EZH2 Genotypes With Oral Cancer Risk

被引：1

作者：

Shih, Liang-Chun ^{[1
]}

Tsai, Chia-Wen ^{[2
,3
]}

Lin, Tzu-Chieh ^{[4
,5
]}

Wang, Yun-Chi ^{[2
,3
]}

He, Jie-Long ^{[6
]}

Hsu, Che-Lun ^{[7
]}

Hsia, Te-Chun ^{[3
]}

Tsai, Fuu-Jen ^{[8
]}

Yang, Jai-Sing ^{[8
]}

Hsu, Yuan-Man ^{[8
]}

Bau, Da-Tian ^{[2
,3
,9
,10
]}

Chang, Wen-Shin ^{[2
,3
,10
]}

机构：

[1] China Med Univ Hosp, Dept Otorhinolaryngol, Taichung, Taiwan

[2] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan

[3] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, Taichung, Taiwan

[4] Taichung Vet Gen Hosp, Dept Emergency Med, Taichung, Taiwan

[5] Tunghai Univ, Coll Fine Arts & Creat Design, Taichung, Taiwan

[6] Asia Univ, Dept Post Baccalaureate Vet Med, Taichung, Taiwan

[7] Asia Univ Hosp, Dept Otorhinolaryngol, Taichung, Taiwan

[8] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[9] Asia Univ, Dept Bioinformat & Med Engn, Taichung, Taiwan

[10] China Med Univ Hosp, Dept Med Res, Terry Fox Canc Res Lab, 2 Yuh Der Rd, Taichung 404, Taiwan

来源：

IN VIVO | 2022年 / 36卷 / 06期

关键词：

Enhancer of zeste homolog 2 (EZH2); genotype; oral cancer; single nucleotide polymorphism; Taiwan; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR-CELL PROLIFERATION; HOMOLOG; EXPRESSION; BETEL QUID; HISTONE METHYLTRANSFERASE; POLYCOMB PROTEIN; ZESTE HOMOLOG-2; BREAST-CANCER; EZH2; SMOKING;

D O I：

10.21873/invivo.13002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background/Aim: The over-expression of enhancer of zeste homolog 2 (EZH2) protein is found in oral cancer tissues. However, the genetic role of the enhancer of EZH2 in the etiology of oral cancer is unknown. The aim of this study was to evaluate the association of EZH2 genotypes with oral cancer risk among Taiwanese. Materials and Methods: Three polymorphic variants of EZH2, rs887569 (C to T), rs41277434 (A to C), and rs3757441 (T to C), were analyzed regarding their association with oral cancer risk among 958 oral cancer patients and the same number of healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In addition, the interaction of EZH2 rs887569, rs41277434, and rs3757441 genotypes with personal behaviors such as smoking, alcohol drinking, and betel quid chewing were also examined.

引用

页码：2669 / 2677

页数：9

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