T cell asymmetry and metabolic crosstalk can fine-tune immunological synapses

被引：5

作者：

Martin-Cofreces, Noa Beatriz ^{[1
,2
,3
]}

Valpuesta, Jose Maria ^{[4
]}

Sanchez-Madrid, Francisco ^{[1
,2
,3
]}

机构：

[1] UAM, Hosp Univ Princesa, Serv Immunol, IIS IP, Madrid 28006, Spain

[2] Fdn Ctr Nacl Invest Cardiovasc Carlos III, Lab Intercellular Commun, Area Vasc Pathophysiol, Madrid 28029, Spain

[3] CIBERCV, Ctr Invest Basica Red Cardiovasc, Madrid 28029, Spain

[4] Ctr Nacl Biotecnol CNB CSIC, Campus Cantoblanco, Madrid 28049, Spain

来源：

TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 08期

关键词：

D O I：

10.1016/j.it.2021.06.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell asymmetry upon specific cellcell interactions during mammalian immunological synapse (IS) contacts requires mammalian target of rapamycin complex (mTORC) activation and chaperones, such as the eukaryotic chaperonin containing TCP1 (CCT) for protein synthesis and folding. This mechanism can control cytoskeleton dynamics, and regulate mitochondrial fate, respiration, and metabolic rates, ultimately underlying cell reprogramming events that are relevant for CD4(+) T cell functional outcomes.

引用

页码：649 / 653

页数：5

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