CG-NAP/Kinase Interactions Fine-Tune T Cell Functions

被引：5

作者：

Verma, Navin Kumar ^{[1
]}

Chalasani, Madhavi Latha Somaraju ^{[2
]}

Scott, John D. ^{[3
]}

Kelleher, Dermot ^{[1
,4
,5
]}

机构：

[1] Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, Singapore, Singapore

[2] Hosp Special Surg, Autoimmun & Inflammat Program, 535 E 70th St, New York, NY 10021 USA

[3] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA

[4] Univ British Columbia, Dept Med, Vancouver, BC, Canada

[5] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC, Canada

来源：

FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷

关键词：

adaptor protein; kinases; CG-NAP; AKAP450; T cell motility; immune synapse; PROTEIN-KINASE-C; ANCHORING PROTEIN; MICROTUBULE NUCLEATION; REGULATORY SUBUNIT; CENTROSOMAL MICROTUBULES; SIGNAL-TRANSDUCTION; SCAFFOLDING PROTEIN; GOLGI-APPARATUS; PKC-THETA; EPSILON;

D O I：

10.3389/fimmu.2019.02642

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

CG-NAP, also known as AKAP450, is an anchoring/adaptor protein that streamlines signal transduction in various cell types by localizing signaling proteins and enzymes with their substrates. Great efforts are being devoted to elucidating functional roles of this protein and associated macromolecular signaling complex. Increasing understanding of pathways involved in regulating T lymphocytes suggests that CG-NAP can facilitate dynamic interactions between kinases and their substrates and thus fine-tune T cell motility and effector functions. As a result, new binding partners of CG-NAP are continually being uncovered. Here, we review recent advances in CG-NAP research, focusing on its interactions with kinases in T cells with an emphasis on the possible role of this anchoring protein as a target for therapeutic intervention in immune-mediated diseases.

引用

页数：12

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