Fc-based half-life extension of human FVIIa - a new player for hemophilia treatment?

被引:0
|
作者
Margaritis, Paris [1 ]
机构
[1] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA
关键词
Hemophilia; Coagulation Factor VIIa; Half-life; Fc fusion; RECOMBINANT FACTOR VIIA; COAGULATION-FACTOR VIIA; ALBUMIN RVIIA-FP; PROPHYLAXIS; INHIBITORS; EFFICACY;
D O I
10.1016/j.thromres.2015.02.030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:775 / 776
页数:2
相关论文
共 50 条
  • [31] Multivalent Albumin-Neonatal Fc Receptor Interactions Mediate a Prominent Extension of the Serum Half-Life of a Therapeutic Protein
    Yang, Byungseop
    Kwon, Inchan
    MOLECULAR PHARMACEUTICS, 2021, 18 (06) : 2397 - 2405
  • [32] Challenges for PEGylated Proteins and Alternative Half-Life Extension Technologies Based on Biodegradable Polymers
    Besheer, Ahmed
    Liebner, Robert
    Meyer, Martin
    Winter, Gerhard
    TAILORED POLYMER ARCHITECTURES FOR PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS, 2013, 1135 : 215 - 233
  • [33] Albumin-based potential drugs: focus on half-life extension and nanoparticle preparation
    Lee E.S.
    Youn Y.S.
    Journal of Pharmaceutical Investigation, 2016, 46 (4) : 305 - 315
  • [34] N8-GP: A new extended half-life recombinant factor VIII product for hemophilia A
    Chowdary, Pratima
    JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 : 3 - 4
  • [35] Modification of the Fc Region of a Human Anti-oncostatin M Monoclonal Antibody for Higher Affinity to FcRn Receptor and Extension of Half-life in Cynomolgus Monkeys
    Nnane, Ivo P.
    Han, Chao
    Jiao, Qun
    Tam, Susan H.
    Davis, Hugh M.
    Xu, Zhenhua
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2017, 121 (01) : 13 - 21
  • [36] Engineered human FcγRIIa fusion: A novel strategy to extend serum half-life of therapeutic proteins
    Jo, Migyeong
    Ko, Sanghwan
    Hwang, Bora
    Min, Sung-Won
    Ha, Ji Yeon
    Lee, Ji Chul
    Jang, Se-Eun
    Jung, Sang Taek
    BIOTECHNOLOGY AND BIOENGINEERING, 2020, 117 (08) : 2351 - 2361
  • [37] A novel in vitro assay to predict neonatal Fc receptor-mediated human IgG half-life
    Souders, Colby A.
    Nelson, Stuart C.
    Wang, Yang
    Crowley, Andrew R.
    Klempner, Mark S.
    Thomas, William, Jr.
    MABS, 2015, 7 (05) : 912 - 921
  • [38] Impact of methionine oxidation in human IgG1 Fc on serum half-life of monoclonal antibodies
    Wang, Weirong
    Vlasak, Josef
    Li, Yunsong
    Pristatsky, Pavlo
    Fang, Yulin
    Pittman, Tamara
    Roman, Jeanette
    Wang, Yang
    Prueksaritanont, Thomayant
    Ionescu, Roxana
    MOLECULAR IMMUNOLOGY, 2011, 48 (6-7) : 860 - 866
  • [39] Switch to extended half-life recombinant factor VIII FC in severe hemophilia A patients under prophylaxis. Experience in one centre
    Jimenez, R.
    Nunez, R.
    Jimenez, P.
    Rodriguez-Martorell, F. J.
    Perez-Simon, J. A.
    HAEMOPHILIA, 2018, 24 : 117 - 117
  • [40] Pharmacokinetic-based prediction of real-life dosing of extended half-life clotting factor concentrates on hemophilia
    Morfini, Massimo
    Gherardini, Stefano
    THERAPEUTIC ADVANCES IN HEMATOLOGY, 2018, 9 (06) : 149 - 162