Secocrassumol, a seco-Cembranoid from the Dongsha Atoll Soft Coral Lobophytum crassum

被引：19

作者：

Cheng, Shi-Yie ^{[1
]}

Wang, Shang-Kwei ^{[2
]}

Duh, Chang-Yih ^{[3
,4
]}

机构：

[1] Natl Univ Kaohsiung, Dept Life Sci, Kaohsiung 811, Taiwan

[2] Kaohsiung Med Univ, Dept Microbiol, Kaohsiung 807, Taiwan

[3] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[4] Kaohsiung Med Univ, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

来源：

MARINE DRUGS | 2014年 / 12卷 / 12期

关键词：

Lobophytum crassum; seco-cembranoid; Mosher's acylation; antiviral activity; NATURAL-PRODUCTS; RED-SEA; DITERPENES; DERIVATIVES; TERPENOIDS; CHEMISTRY; DURUM; OCTOCORALLIA; COLLECTION;

D O I：

10.3390/md12126028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical investigations on the Dongsha Atoll soft coral Lobophytum crassum led to the purification of a new seco-cembranoid, secocrassumol. The structural elucidation was established by extensive NMR, HRESIMS and CD data. The absolute configuration at C-12 was determined as S using a modified Mosher's acylation. Secocrassumol differs from previously known marine seco-cembranoid in that it possesses an unprecedented skeleton functionalized at C11-C12 bond cleavage. Secocrassumol showed antiviral activity against human cytomegalovirus (HCMV) with an IC50 value of 5.0 mu g/mL.

引用

页码：6028 / 6037

页数：10

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