Resolution of (±)-mandelic- and (±)-2-(chlorophenoxy)propionic-acid derivatives by crystallization of their diastereomeric amides with (R)- or (S)-α-arylethylamines

被引：4

作者：

Jourdain, F

Hirokawa, T

Kogane, T

机构：

[1] Kanagawa Ind Technol & Res Inst, Fundamental Technol Div, Kanagawa 2430435, Japan

[2] Yokohama Natl Univ, Ctr Corp Res & Dev, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(99)00169-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An alternative and cost effective route for the resolution in high ees (95-99%) of (+/-)-mandelic- and (+/-)-2-(chlorophenoxy)propionic- acid derivatives is reported. The key step involves the covalent derivatization and separation of their diastereomeric amides with (R)- or (S)-alpha-arylethylamines. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2307 / 2310

页数：4

共 49 条

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[43] THIOL-BASED INHIBITORS OF MAMMALIAN COLLAGENASE - SUBSTITUTED AMIDE AND PEPTIDE DERIVATIVES OF THE LEUCINE ANALOG, 2-[(R,S)-MERCAPTOMETHYL]-4-METHYLPENTANOIC ACID
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[46] AMPA receptor agonists: Resolution, configurational assignment, and pharmacology of (+)-(S)- and (-)-(R)-2-amino-3-[3-hydroxy-5-(2-pyridyl)isoxazol-4-yl]-propionic acid (2-Py-AMPA)
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