Azathioprine in inflammatory bowel disease, a safe alternative?

被引：20
|
作者：
Tanis, AA [1 ]
机构：
[1] Erasmus Univ, Hosp Dijkzigt, Dept Gastroenterol & Hepatol, NL-3015 GD Rotterdam, Netherlands
来源：
MEDIATORS OF INFLAMMATION | 1998年 / 7卷 / 03期
关键词：
azathioprine; 6-mercaptopurine; inflammatory bowel disease; bone marrow suppression; side effects; pregnancy;
D O I：
10.1080/09629359891045
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
AZATHIOPRINE and its metabolite 6-mercaptopurine are effective in the treatment of inflammatory bowel disease. They are mostly used for reduction of the use of steroids, maintenance therapy after remission induction by cyclosporin and treatment of fistulae in Crohn's disease. Adverse effects occur in about 15% of patients. The main side effects are pancreatitis, allergic reactions, fever and bone marrow suppression. Symptoms, management and prevention are discussed. A blood monitoring schedule is suggested. Azathioprine and 6-mercaptopurine seem to be safe in pregnancy. There may be a slight increased risk for developing a non-Hodgkin's lymphoma.
引用
收藏
页码：141 / 144
页数：4
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