IL-6 and IL-10 promoter gene polymorphisms in psoriasis vulgaris

被引：36

作者：

Baran, Wojciech ^{[1
]}

Szepietowski, Jacek C. ^{[1
,2
]}

Mazur, Grzegorz ^{[3
]}

Baran, Eugeniusz ^{[1
]}

机构：

[1] Polish Acad Sci, Dept Dermatol Venerol & Allergol, PL-50368 Wroclaw, Poland

[2] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-50368 Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Haematol Blooc Neoplasms & Bone Marrow Trans, Wroclaw, Poland

来源：

ACTA DERMATO-VENEREOLOGICA | 2008年 / 88卷 / 02期

关键词：

IL-10; IL-6; single nucleotide polymorphism; psoriasis;

D O I：

10.2340/00015555-0427

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide polymorphisms and susceptibility to psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers was investigated. IL-6 promoter gene single nucleotide polymorphisms in position -174, and IL-10 single nucleotide polymorphisms in positions -1082, -819 and -592 were evaluated by polymerase chain reaction using sequence-specific primers. No significant differences were found in the polymorphisms of IL-6 and IL-10 promoter genes between patients with psoriasis and healthy controls.

引用

页码：113 / 116

页数：4

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