IL-6 and IL-10 promoter gene polymorphisms in psoriasis vulgaris

被引：36
|
作者：
Baran, Wojciech [1 ]
Szepietowski, Jacek C. [1 ,2 ]
Mazur, Grzegorz [3 ]
Baran, Eugeniusz [1 ]
机构：
[1] Polish Acad Sci, Dept Dermatol Venerol & Allergol, PL-50368 Wroclaw, Poland
[2] Polish Acad Sci, Inst Immunol & Expt Therapy, PL-50368 Wroclaw, Poland
[3] Wroclaw Med Univ, Dept Haematol Blooc Neoplasms & Bone Marrow Trans, Wroclaw, Poland
来源：
ACTA DERMATO-VENEREOLOGICA | 2008年 / 88卷 / 02期
关键词：
IL-10; IL-6; single nucleotide polymorphism; psoriasis;
D O I：
10.2340/00015555-0427
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Overexpression of IL-6 has been implicated in the pathology of numerous autoimmune and chronic inflammatory diseases, including psoriasis, and relative deficiency of IL-10 in psoriatic patients seems to be important in the development of this disease. The aim of this study was to investigate the association between IL-6 and IL-10 single nucleotide polymorphisms and susceptibility to psoriasis vulgaris. DNA from 78 patients with psoriasis vulgaris and 74 healthy volunteers was investigated. IL-6 promoter gene single nucleotide polymorphisms in position -174, and IL-10 single nucleotide polymorphisms in positions -1082, -819 and -592 were evaluated by polymerase chain reaction using sequence-specific primers. No significant differences were found in the polymorphisms of IL-6 and IL-10 promoter genes between patients with psoriasis and healthy controls.
引用
收藏
页码：113 / 116
页数：4
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